Chapter 5: PSY-432 (1267-11239) PSYCHOPHYSIOLOGY DRUGS AND BEHVR (Fall 2026 M16) 002

What is cocaine's therapeutic index?

 

25

 

15

 

100

 

75

15

Which route of administration of cocaine gets into the brain the fastest?

 

Smoking

 

Snorting the powder

 

Injection

 

Oral

Smoking

Of the following routes of administration, which are in order from fastest onset of action to slowest?

 

Smoked → oral → snorted → injected

 

Snorted → injected → oral → smoked

 

Injected → snorted → oral → smoked

 

Smoked → injected → snorted → oral

 

Smoked → injected → snorted → oral

When taken with cocaine, alcohol forms a new compound in the body that essentially inactivates cocaine's actions.

 

False

 

True

False

Which of the following effects of cocaine is not due to dopamine?

 

Repetitive and compulsive movements

 

Dilating the bronchi and increasing heart rate

 

Influencing planning, problem-solving, and decision-making

 

Motivation, reward, and addiction

Dilating the bronchi and increasing heart rate

Which of the following is true of cocaine?

 

It increases the amount of dopamine in the synapse.

 

It increases the actions of the parasympathetic nervous system.

 

It slows heart rate and reduces blood pressure.

 

It is a medically approved treatment for glaucoma.

It increases the amount of dopamine in the synapse.

Repeated use of amphetamine over days or weeks can lead to a psychotic state that resembles schizophrenia.

 

False

 

True

True

The Anti-Drug Abuse Act of 1986 declared that distribution of 5 grams of crack cocaine carried the same mandatory minimum sentence as distribution of 500 grams of powder cocaine.

 

True

 

False

True

Cocaine blocks sodium channels in pain pathways.

 

False

 

True

True

Approximately _______ of the U.S. population has used cocaine at least once in their lives.

 

15%

 

2%

 

5%

 

10%

15%

Which of the following is false about levamisole?

 

It inhibits the psychoactive effects of cocaine.

 

It has dangerous effects on the bone marrow.

 

It is a drug to treat parasitic warm infections.

 

Over 80% of cocaine shipments seized in the U.S. were cut with levamisole.

It inhibits the psychoactive effects of cocaine.

Which is true about cocaine's effects as a local anesthetic?

 

Lidocaine, Novocain, and cocaine have identical physiological effects.

 

Cocaine is a schedule I drug, but doctors have been given special dispensation to use it.

 

Cocaine's effects as a local anesthetic last for up to 100 hours.

 

Cocaine constricts blood vessels in the face, making it an effective local anesthetic for oral and facial surgery.

Cocaine constricts blood vessels in the face, making it an effective local anesthetic for oral and facial surgery.

What is cocaethylene?

 

The generic name of the medicinal form of cocaine available to surgeons

 

The chemical name of crack cocaine

 

A compound that forms when cocaine is taken concurrently with alcohol

 

The genus name of the coca plant

A compound that forms when cocaine is taken concurrently with alcohol

Blocking _______ is not a mechanism by which cocaine exerts its effects.

 

reuptake of dopamine

 

reuptake of acetylcholine

 

reuptake of serotonin

 

sodium channels in pain pathways

reuptake of acetylcholine

Which is true about cocaine use during pregnancy?

 

80% of babies born of cocaine-using mothers have been proven to have life-long adverse effects.

 

Cocaine's effects on the fetus are comparable to those of tobacco.

 

Cocaine increases blood flow to the placenta.

 

Cocaine reduces the risk of stillbirth.

Cocaine's effects on the fetus are comparable to those of tobacco.

Which statement accurately compares amphetamine to cocaine?

 

Amphetamine is less addictive than cocaine.

 

Amphetamine is metabolized more slowly than cocaine.

 

Unlike cocaine, amphetamine is not metabolized by the Cytochrome P450 system.

 

Amphetamine can be ingested, injected, and snorted, but not smoked.

Amphetamine is metabolized more slowly than cocaine.

_______ is not one of the adverse effects of cocaine.

 

Reduced risk of seizure

 

Perforation of the nasal septum

 

Increased risk of stroke

 

Increased risk of heart attack

 

Reduced risk of seizure

Which is NOT one of the ways amphetamine increase levels of dopamine in the synapse?

 

Blocks reuptake

 

Binds directly to postsynaptic receptors

 

Increases release

 

Inhibits MAO

 

Binds directly to postsynaptic receptors

Which is true about the forms of amphetamine?

 

Methamphetamine crosses the BBB fastest.

 

Amphetamine itself is not able to cross the BBB.

 

Dextro-amphetamine is the left-handed derivative.

 

Levo-amphetamine is the most lipid soluble form.

Methamphetamine crosses the BBB fastest.

The brains of chronic cocaine users show

 

signs of reduced aging.

 

a loss of the neuronal connections that run from the medulla to the heart.

 

more neuronal connections in the temporal lobe.

 

a loss of tissue in the prefrontal cortex.

a loss of tissue in the prefrontal cortex.