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Condensation Reaction
Chemical reaction used to produce polymers
Involves the loss/production of a water molecule
Condensation Reactions Link Nucleotides Into a Polymer
Nucleotide monomers are joined by condensation reactions
Each reaction forms a phosphodiester bond and releases a molecule of water
The polymer grows in the 5' to 3' direction as new nucleotides are added to the 3' end.
Forms RNA polymer

Ligase
Enzyme that joins two molecules together by forming a bond between them
DNA ligase helps seal the sugar-phosphate backbone by joining DNA fragments
5’ to 3’
Direction a nucleic acid strand is built and read
5' end = phosphate end
3' end = hydroxyl end