cytochrome P450

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Last updated 2:11 PM on 4/28/26
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6 Terms

1
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how do enzyme inducers affect cytochrome p450?

increase effect of cytochrome p450 so decrease the effect of the drugs ( more broken down)

2
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how do enzyme inhibitors affect cytochrome p450?

decrease the effect of cytochrome p450 so increases the effect of the drugs as less broken down

3
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how does cytochrome p450 break down drugs?

oxidative metabolism - cytochrome p450 monooxygenase system

4
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where does the oxidative metabolism mainly take place?

the liver

5
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what are some common CYP450 inhibitors?

MO DEVICES GA

Metronidazole

Omepraxole

Disulfiram

Erythromycin (macrolides)

Valproate

Isoniazide

Ciprofloxacin (quinolones)

Ethanol (acute)

Sulphonamides

Grapefruit juice

Antifungals

THESE INCREASE EFFECT OF DRUG

6
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what are some common CYP450 inducers?

PCCARBSSS

Phenytoin

Carbamezapine

Corticosteroids

Alcohol (chronic)

Rifampicin

Barbiturates

Sulponylurea

Smoking

St Johns wart

THESE DECREASE THE EFFECT OF THE DRUG