IF4- steriodal and non steroidal anti- inflammatory treatments

what are steriods + how they can be made + how they have an effect 

• they are hormones that are derived from mevalonic acid 

• the enyme that produces mevalonic acid ( HMG-CoA reductase ) is the drug target for satins which are used to treat high cholesterol 

• the first steriod is lanosterol which is converted into cholesterol 

• then several different classes of steriods hormones are derived from cholesterol by modification of its structure 

• the different steriods bind to specific steriod receptors allowing the transcription of genes 

describe the formation of steriods/ whats the step by step process 

describe the basic structure of steriods 

describe the 4 main glucocorticoids + their functions 

what are non steriodal anti-inflammatory drugs ( NSAIDS ) 

describe how aspirin acts as a non steriodal anti inflammatory drug 

describe how ibuprofen and related drugs like naproxen work as non steroidal anti-inflammatory drugs 

describe the activation of ibuprofen ( r->s )

• when ibuprogen is first bought its found in a mixture of its r and s enantiomer 

• this is bacuse the r can be converted into the s- pharmacological activation 

• the body attaches CoA  onto the r enantiomer to creat an intermediate 

• then the molecule changes its 3d arragngment to form the s enantiomer 

• finally the CoA is removed 

what is diclofenac 

its an NSAID used to reduce pain inflammation and swelling 

whats the main side effect of drugs that have activity against COX 2 e.g  ibuprofen diclofenac , naproxen and aspirin and other selective inhibitors 

they can lead to cardiovascular complications

what’s the main side effect of drugs that inhibit the COX1 enzymes 

they can lead to gastrointestinal complications