PK5/6-multiple dose regimens 1

0.0(0)
Studied by 0 people
call kaiCall Kai
learnLearn
examPractice Test
spaced repetitionSpaced Repetition
heart puzzleMatch
flashcardsFlashcards
GameKnowt Play
Card Sorting

1/12

encourage image

There's no tags or description

Looks like no tags are added yet.

13 Terms

1
New cards

what is a therapeutic window 

its the range of concentrations where the success of the therapy is optimal/ the concentrations where the drug will be most effective and not harmful to the patient 

2
New cards

what’s the equation used for a multiple regimen  iV bolus when your trying to calculate the amount of drug left over after a certain amount of time 

knowt flashcard image
3
New cards

when observing plasma profiles for drugs being given at interval administration what does the peak and the dip mean 

the peak ( Amax ) is the amount of drug in the body just after the injection has been given this includes whats been just given and what is left over from the previous dose 
the dip is the decline seen before the next dose is given and its the drug concentration left in the body 

4
New cards

descirbe what happens during the steady state of a multiple dose regimen 

during the steady state the plasma concentration profiles versus time throughout the dosing interval are the same for all doses in the steady state 

<p><span>during the steady state the plasma concentration profiles versus time throughout the dosing interval are the same for all doses in the steady state&nbsp;</span></p>
5
New cards

describe the AUC when the a steady state in multiple dose regimens 

  • when the SS has been reached the steady state for each interval becomes the same and it can be described as:

  • its independant of the time of tau ( the time between the doses )


<ul><li><p>when the SS has been reached the steady state for each interval becomes the same and it can be described as:</p></li><li><p>its independant of the time of tau ( the time between the doses )</p></li></ul><p></p>
6
New cards

describe the relation between  the rate of drug in and out during the steady state

rate in = rate out 

<p><span>rate in = rate out&nbsp;</span></p>
7
New cards

how do u calculate the concentration in a steady state 

knowt flashcard image
8
New cards

what does the number of doses it takes to reach steady state depend on 

knowt flashcard image
9
New cards

when considering steady state concentration what does F mean 

it means the fraction of steady state attained 
so the concentration at any number of doses divided by the concentration at the steady state 

<p><span>it means the fraction of steady state attained&nbsp;</span><br><span>so the concentration at any number of doses divided by the concentration at the steady state&nbsp;</span></p>
10
New cards

whats the equation to calculate the time it takes to reach a certain fraction of the steady state 

knowt flashcard image
11
New cards

what’s the equation to work out the number of doses it takes to reach a fraction of the steady state 

knowt flashcard image
12
New cards

what is fluctuations in terms of steady state concentration and multiple dose regimens 

 

<p><span>&nbsp;</span></p>
13
New cards

how do you calculate the extent of accumulation/the accumulation ratio

knowt flashcard image