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Antigen
Substance recognized by adaptive system
Epitope
Part of antigen recognized by TCR
Antigen can have multiple epitopes
Haptens
Small molecules that only become immunogenic when attached to larger carrier protein
Ex: penicillin-protein complex can trigger allergic immune response
Type I Hypersensitivity (allergy)
IgE binds to mass cells causing them to release histamine and provoke allergic reactionT
Type II Hypersensitivity
IgG/IgM mediation
Ex: ABO blood transfusion, Rh hemolytic newborn disease
Central memory T cells (Tcm)
mainly circulate through lymphoid organs → rapid proliferation
Effector memory T cells (Tem)
circulate through blood and peripheral tissues