Immunology cytokines/T cells

IFN-y

Produced by what T cell:

T cells function:

Function:

Produced by what T cell: TH1

T cells function: Activate/enhance macrophages

Function: 1st signal required to enhance macrophages

CD40L

On what cells:

T cells (TH1, TFH)

CD40

On what cells: 2

Macrophages (TH1), B cells (TFH)

IL-17

Produced by what T cell:

T cells function:

Function:

Produced by what T cell: TH17

T cells function: activate neutrophils to clear extracellular bacteria and fungi

Function: induces expression of chemokines, recruiting neutrophils to infection

IL-5

Produced by what T cell:

T cells function:

Function:

Produced by what T cell: TH2

T cells function: activate B cells and granulocytes

Function: activate granulocytes

IL-4 (2)

Produced by what T cell:

T cells function:

Function:

Produced by what T cell: TH2

T cells function: activate B cells and granulocytes

Function: influence B cells to class switch to produce IgE antibodies

Produced by what T cell: TFH

T cells function: activate B cells for immunoglobulin production

Function: promote clonal expansion of B cells

IL-13

Produced by what T cell:

T cells function:

Function:

Produced by what T cell: TH2

T cells function: activate B cells and granulocytes

Function: stimulate GI peristalsis and mucus production

IL-21

Produced by what T cell:

T cells function:

Function:

Produced by what T cell: TFH

T cells function: activate B cells for immunoglobulin production

Function: promote B cell differentiation into plasma cells

IL-10

Produced by what T cell:

T cells function:

Function:

Produced by what T cell: TFH

T cells function:

Function:

TGF-B

Produced by what T cell:

T cells function:

Function:

Produced by what T cell: Treg

T cells function: Modulate immune response, maintains tolerance of self-antigens, prevents autoimmunity

Function: immune inhibitory cytokine

FOXP3

Produced by what T cell:

T cells function:

Function:

Produced by what T cell: Tregs

T cells function: Modulate immune response, maintains tolerance of self-antigens, prevents autoimmunity

Function: immune supression

CTLA-4

Produced by what T cell:

T cells function:

Function:

Produced by what T cell: Tregs

T cells function: Modulate immune response, maintains tolerance of self-antigens, prevents autoimmunity

Function: suppress T cell activation

TH1

Enhances Macrophages

TH2

Activate B cells and granulocytes

TH17

Activate neutrophils to clear extracellular bacteria and fungi

TFH

Activate B cells for immunoglobulin production

Treg

Modulate immune response, maintains tolerance of self-antigens, prevents autoimmunity