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What triggers IFN-α and IFN-β production
Viral infection
What do IFN-α and IFN-β activate
Over 50 antiviral genes
Why must the IFN response be tightly regulated
It should only activate during viral infection
How many transcription factor binding sequences exist in the IFN-β enhancer
Four
What is the enhanceosome
A complex of transcription factors assembled on the IFN-β enhancer
Which co-activators are recruited by the enhanceosome
p300 and CBP
Why are co-activator interactions usually weak
To favour complex formation only at correct promoters