Cardiac Drug Classifications

Cardiac Output

Amount of bld ejected by each ventricle in one min

Heart Rate

• Conduction system of the heart

• The BPM

Stroke Vol

Vol of blood pumped by each ventricle

Dromotrophic (Rhythm/Conduction)

• (+) Actn = Increased conduction

• (-) Actn = Decreased conduction

Chronotrophic (Rate)

• (+) Actn = Increased HR

• (-) Actn = Decreased HR

Inotrophic (FOC)

• (+) Inotrophic = Increased FOC

• (-) Inotrophic = Decreased FOC

ACE Inhibitors Action

• Prevents conversion of Angiotensin I to II

• No Angiotensin II = No aldosterone release

• Inhibits Inactivation of autacoid bradykinin done by ACE

Results of Taking ACE Inhibitors

• Vasodilation + Decreased bld vol

• Decreased bld vol from Na + H2O excretion

ACE Inhibitors are used for

• Hypertension

• CHF

ACE Inhibitors Contraindications

• Pregnancy

• Existing Renal Failure (bcs less

ACE Inhibitors Adverse Effects

• Hypotension

• Renal insufficiency

• Hyperkalemia

• Dry cough

Examples of ACE Inhibitors

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• Captopril

• Enalapril

• Ramipril

Angiotensin Receptor Blockers Action (ARBS)

Block angiotensin II receptors in:

• Vascular Smooth Muscle

• Adrenal Cortex

Results of Taking ARBS

• Vasodilation

• Increased Na+ output + H2O since aldosterone isn’t released

ARBS are used for

Treat hypotension

ARBS Contraindications

• Pregnancy (fetotoxic)

• Renal Pathology

ARBS Adverse effects

• Hypotension

• GI complaints (nausea/Diarrhea)

• Dry mouth

ARBS Examples

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• Candesartan (Atacand)

• Iosartan (Cozaar)

• ibesartan (Avapro)

Beta Adrenergic Blockers Action

• SNS Antagonist = SYMPATHOLYTIC

• Negative inotrophic, dromotrophic, chronotrophic effects

Beta Adrenergic Blockers are used for

• Angina

• HTN

• Cardiac dysrthmias

• USED AS POST MI TREATMENT

Beta Adrenergic Blockers Contraindications

• Sinus Bradycardia

• Heart Blocks

• Hypotension

Beta Adrenergic Blockers Adverse Effects

• Hypotension

• Fluid Retention (bcs backing up fluid)

• Heart Blocks

• Bradycardia

• Fatigue

Beta Adrenergic Blockers Examples SELECTIVE BETA 1

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Beta Adrenergic Blockers Examples NON-SELECTIVE B1 + B2

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Calcium Channel Blockers Action