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What are antioxidants?
Substances that neutralise reactive free radicals
What are free radicals?
Highly reactive molecules that can damage cellular components
How may free radicals contribute to atherosclerosis?
They can oxidise LDL which may promote inflammatory plaque formation
How might dietary antioxidants reduce CVD risk?
They may neutralise free radicals and reduce LDL oxidation
Does a proposed antioxidant mechanism prove reduced CVD risk?
No; clinical evidence is needed to establish an effect on disease outcomes
How should studies of antioxidants be evaluated?
Consider study design sample size confounding variables and whether results show causation