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Membrane
surface of the cell separating it from the outside environment
Nucleus
contains chromosomes/genetic material
Mitochondrion
performs metabolic activities and provides energy, has mtDNA separate from autosomal DNA
Ribosomes
synthesize new protein molecules
endoplasmic reticulum
network of thin tubes to transport synthesized proteins
Neuron
Brain cells
Motor Neurons
conducts impulses along axon to a muscle
Sensory Neurons
specialized, highly sensitive to a type of stimulation
Dendrites
branching fibers lined with synaptic receptors to receive information from other neurons. The greater the surface area, the more information it can receive.
Dendritic spines
small nubs along dendrites that increase the surface area
Soma
cell body of a neuron, containing the nucleus, ribosomes, and mitochondria -- the center for metabolic work
Axon
thin fiber with consistent diameter, conveys electrical impulse toward other neurons, organ, or a muscle
Myelin sheath
insulating material on vertebrate axons with interruptions called Nodes of Ranvier, lipids/fatty tissue
Nodes of Ranvier
interruptions along the myelin sheath of a neuron
Presynaptic Terminal
swelling on the end of axon branches where exons release chemicals that cross through junction between neuron cells
Efferent Axon
carries information away from a structure
Afferent Axon
brings information to a structure
intrinsic neuron
when a neuron cell's axons and dendrites are entirely contained within a single structure
Glia
non-neuronal cells in the brain that use chemical signaling instead of electrical signaling
Astrocytes
star-shaped glia that wrap around synapses of functionally related neurons, shielding them from chemicals. They take up and re-release ions released by axons. They synchronize closely related neurons, enabling message waves and rhythm mechanisms. They also dilate blood vessels in the brain to increase nutrient flow and activity of neurons
Tripartite Synapse
when the tips of an axon releasing chemicals causes a neighboring astrocyte to release its own chemicals, magnifying or modifying the message to the next neuron
Microglia
immune agents of the brain, they remove virus/fungi, dead or damaged neurons post brain damage, and the weakest synapses.
Oligodendrocytes
In the CNS, build myelin sheaths that insulate axons and supply axons with nutrients
Schwann Cells
In the PNS, build myelin sheaths that insulate axons and supply axons with nutrients
Radial Glia
guide the migration of new neurons during embryonic development, and they turn to neurons/astrocytes/oligodendrocytes after that stage of brain development is finished
Active transport
protein-mediated process, expending energy to pump chemicals from the blood into the brain
Sodium-Potassium Pump
protein complex that transports sodium ions out and potassium ions into the neuron using active transport
Action Potential
electrical messages sent by axons
Central Nervous System (CNS)
the brain and spinal cord
Peripheral Nervous System (PNS)
motor and sensory neurons
Extracellular fluids
salty from sodium, fluids in the body not contained in cells
Reflex Arc
the circuit from a sensory neuron to muscle response, found by Charles Scott Sherrington
Presynaptic Neuron
neuron that delivers transmission in reflex arc
Postsynaptic Neuron
neuron that receives transmission in reflex arc
Interneuron
an intermediate neuron or relay neuron, specialized nerve cells that connect other neurons in the CNS, mainly linking sensory neurons to motor neurons
Neurotransmitters
chemicals that affect another neuron
Vesicles
tiny, nearly spherical packets where neurotransmitters are stored
Glutamate
most abundant excitatory neurotransmitter released by nerve cells in your brain, found in ctenophores/least-evolved creatures like jellies as well as other animals, meaning it evolved very early on
Nitric Oxide
neurotransmitter that dilates blood vessels, increasing blood flow to the brain
Catecholamines
compounds containing a catechol and an amine group
Tryptophane
precursor to serotonin
Insulin
takes competing amino acids against tryptophane out of the bloodstream and into body cells, has high permeability
L-DOPA
precursor to dopamine and increases dopamine, used as treatment for Parkinson's Disease
MAO
monoaminoxidase, breaks down serotonin, dopamine, or norepinephrine after synaptic signaling
GABA
gamma-aminobutyric acid, used in most inhibitory ionotropic(fast-acting) synapses but also in some metabotropic
Glycine
common inhibitory transmitter found primarily in the spinal cord
Acetylcholine
often excitatory and found in many ionotropic(fast-acting) synapses, widens the sodium channels
Dopamine
neurotransmitter known for its role in the "reward system", metabotropic(slow-acting) processes
Norepinephrine
neurotransmitter also known as adrenaline, used in metabotropic synapses
Serotonin
neurotransmitter used in metabotropic processes, carries messages between nerve cells in the brain and throughout your body
Monoamine Neurotransmitter
neurotransmitters and neuromodulators that contain one amino group connected to an aromatic ring by a two-carbon chain. Examples are dopamine, norepinephrine and serotonin.
G Protein
protein coupled to guanosine triphosphate(GTP), an energy storing molecule. It results in increased second messaging concentration during a synaptic reaction
Neuropeptide/neuromodulators
synthesized in the cell body and slowly transported to other parts of the cell, released by dendrites and other parts of the neuron. They require repeated stimulation to be released
Synapse
the junction between the axon tip of the sending neuron and the dendrite or cell body of the receiving neuron
Ionotropic Receptors
allow change in postsynaptic cell to happen directly and quickly, ligand-gated ion channels open
Metabotropic Receptors
allow change after postsynaptic cell to happen gradually and more indirectly, through a sequence of cellular messages
Monoamines
serotonin, dopamine, norepinephrine, and epinephrine; associated with movement, learning, memory, mood, etc..
Lamina
row or layer of cell bodies separated from other cell bodies by a layer of axons and dendrites
Column
a set of cells perpendicular to the surface of the cortex, with similar properties
Tract
set of axons within the CNS, also known as a projection, they extend from one structure to another
Nerve
set of axons in the PNS, either from the CNS to a muscle/gland or from a sensory organ to the CNS
Nucleus (neuroanatomy)
cluster of neuron cell bodies within the CNS
Ganglion
cluster of neuron call bodies usually outside the CNS (in the sympathetic nervous system)
Gyrus
protuberance/bump on the brain surface
Sulcus
fold/groove separating gyruses
Fissure
a long, deep sulcus
Dorsal
toward the back
Ventral
toward the stomach
Anterior
toward the front end
Posterior
toward the back end
Superior
above another part
Inferior
below another part
Lateral
toward the side, away from the midline
Medial
toward the midline, away from the side
Proximal
approximate/close to the point of origin
Distal
distant from the point of origin
ipsilateral
on the same side of the body
Contralateral
on the opposite side of the body
Somatic Nervous System
PNS, axons conveying messages from the sense organs to the CNS and from the CNS to the muscles -- regulation of voluntary control
Autonomic Nervous System
PNS, controls the heart, intestines, and other organs. Some cell bodies within the brain or spinal cord, and some clustered along the sides of the spinal cord -- regulation of involuntary control
Spinal Cord
CNS, within spinal column. It communicates with all the sense organs and muscles except those of the head
Dorsal Root Ganglion
clusters of neurons of cell bodies of sensory neurons outside the spinal cord
Gray Matter (spinal cord)
H-shaped center of the cord, packed densely with cell bodies and dendrites
White Matter (spinal cord)
around the gray matter, contains myelinated axons
Sympathetic Nervous System
network of nerves that prepare the organs for a burst of vigorous activity, consisting of ganglia chains just to the left and right of the spinal cord's central regions. It helps prepare for "fight or flight"
Parasympathetic Nervous System
facilitates vegetative, nonemergency responses. Generally, the opposite of the sympathetic nervous system -- "rest and digest"
Hindbrain
posterior part of the brain, consists of the medulla, pons, and cerebellum (brainstem)
Medulla
enlarged extension of the spinal cord, moderates breathing, blood pressure, and heart rate
Cranial Nerves
12 pairs of nerves in the medulla which control vital reflexes like breathing, heart rate, vomiting, salivation, coughing, and sneezing
Pons
anterior and ventral to the medulla, also contains nuclei for several cranial nerves. It's the "bridge" between the left and right hemispheres with opposite sides of the spinal cord
Cerebellum
control of movement, shifting attention between stimuli, judging timing, and some types of learning and conditioning. It's sometimes called the "mini brain", and has a unique "tree of life" pattern inside
The Midbrain
in the middle of developing brains, but is dwarfed and surrounded by the forebrain in mammalian adulthood
Tectum
roof of the midbrain
superior and inferior colliculi
swellings on each side of the tectum, important for sensory processing. Inferior = hearing and superior = vision
Tegmentum
under tectum, intermediate level of the midbrain
Substantia Nigra
gives rise to dopamine, and contains a pathway that facilitates readiness for movement
The Forebrain
most prominent part of the mammalian brain, consists of two cerebral hemispheres - one left and one right - with each hemisphere organized to receive sensory information, mostly from the opposite(contralateral) side of the body
Cingulate Gyrus
on the prefrontal cortex interface, assists with conflict resolution and error detection (when reality doesn't align with what's expected)
Cerebral Cortex
outer portion of the forebrain
Limbic System
"limbus"=border, around the brainstem. it includes the olfactory bulb, hypothalamus, hippocampus, amygdala, and the cingulate gyrus of the cerebral cortex