Pyruvate Dehydrogenase Complex

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Last updated 5:37 AM on 8/25/26
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10 Terms

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Goal

Oxidative decarboxylation of pyruvate to become Acetyl-CoA

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E1

Pyruvate Dehydrogenase

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E2

Dihydrolipoyl transacetylase

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E3

dihydrolipoyl dehydrogenase

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Prosthetic Groups

TPP, lipoyllysine, FAD

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Co-subtrates

NAD+ and CoA-SH

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Substrate channeling

keeps intermediates on surface, keeps local substrate concentration high, and prevents theft of active acetyl group

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Vitamin B1

TPP

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Vitamin B3

NAD+

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Vitamin B5

pantothenic acid (in CoA)