week 3 (coag cascade)

what is the name of factor 1

fibrinogen

what is the reference range for fibrinogen?

200-400 mg/dL

what clotting factors are part of the fibrinogen group?

factors 1, 5, 8, and 13

what clotting factors are part of the prothrombin group?

factors 2, 7, 9, 10

which clotting factors are thrombin sensitive?

factors 1,5,8,13

which factors are vitamin K dependent?

factors 2, 7, 9, 10

what are the contacts clotting factors?

11, 12, HMW Kininogen, pK

Factor 1 also called ______ is activated by _______ to become _______. It is made in the _____ can be replaced via transfusion as _____ and it’s molecule type is _____.

Fibrinogen, thrombin, fibrin, liver, cryoprecipitate, soluble globulin

Factor 2 also called ______ is a ________. it is made in the ______ is vitamin k ________ (dependent/independent) is activated by factor _______ and factor ______ and turns ______ into _____. It’s reference range is _______.

Prothrombin, serine protease, liver, dependent, 10a, 5a, prothrombin, thrombin, 8-15 mg/dL

Factor 3 also called _______ or _______ is a __________. its intrinsic form is in the _____ and its extrinsic form is in ______. the intrinsic form is secreted in cases of _____. The extrinsic form needs a little of factor ____ to become activated and activates factor _____.

tissue factor, tissue thromboplastin, high molecular weight lipoprotein, plasma, platelets, tissue damage, 9, 7

Factor 4 also called ______ is required to activate ______. Factor 4 acts as a bridge between ______ and ______.

calcium, thromboplastin, platelet phospholipid, clotting factors

Factor 5 also called _______ or _____ is a ______. it is made in the ____. Factor 5 is activated by ____ and amplifies the transformation of factor ____ to factor ___. A mutation of factor 5 Leiden can lead to ____ by changing the ____ of factor 5 and making it more resistant to the binding of ____ and _____

proaccelerin, labile factor, globulin, liver, thrombin, 2, 2a, thrombosis, structure, protein C, Protein S

Factor 7 also called ______ or _______ is a _______. it is activated by _____. It is vitamin K _____ (dependent/independent) and activates factors _____ and _____. It is made in the ____

proconvertin, stable factor, globulin serine protease, factor 3, dependent, 9, 10, liver

Factor 8 also called ______ is a _____. it is made up of 2 sub units ______ and _____. Deficiency of ____ causes the disease _____ where as a deficiency of ____ causes the disease ______. The sub unit ____ functions with factor 9 to convert ____ into _____. If the subunit _____ is absent adding ______ will induce platelet aggregation

Antihemophilic factor, glycoprotein, 8C, vWF, 8C, Hemophilia A, vWF, Van Willebrand’s disease, 8C, factor 10, factor 10a, vWF, Ristocetin

Factor 9 also called _______ or ______ is a ______ made in the ______. It is vitamin K _______ (dependent/independent) and is activated by factors ______ and ______. Together with factors _____, _______, and _____ it helps catalyze the activation of factor _____. Deficiency in factor 9 leads to a condition called _______.

Plasma thromboplastin, Christmas factor, stable protein, liver, dependent, 7a, 11a, 8, 4, pF3, 5, Hemophilia B

Hemophilia a is a clotting disorder caused by a deficiency in factor _____. It is an inherited disorder found on the _____ chromosome and due to being _____ most often effects newborn boys.

8, x, recessive

Factor 10 also known as ______ is a _______ made in the _____. It is vitamin K ______ (dependent/independent) and is activated by factors ____ and _____.

Stuart Prower, stable globulin, liver, dependent, 9, 8

Factor 11 also called _____ is a ____ made in the _____ and is vitamin K ______ (dependent/independent). It circulates as a complex with ______ and is activated by factors _____ and ______. It activates factor _____ and a deficiency in factor 11 can cause a condition called _______.

Plasma thromboplastin antecedent, globulin, liver, independent, HMWK, 2a, 12a, 9, Hemophilia C

Factor 12 also called ______ or ______ or ________ is a ______ made in the _____. It is vitamin K (dependent/independent) _________ and can become activated by ______. It activates factor ____.

Hageman factor, contact factor, glass factor, stable globulin, liver, independent, contact with glass, 11.

Factor 13 also called ____ includes the enzyme ____ which catalyzes fibrin polymerization, subunit alpha is made by _____ and includes ______ and subunit beta is made in the ____ and includes _____. the alpha sub unit acts as a ____ whereas the beta subunit acts as a _____. Both are inhibited by the addition of _____. and neither are detected on a _____ or a _____.

Fibrin stabilizing factor, fibrinase, megakaryocytes, platelet factor 3, liver, plasma fibrin stabilizing factor, catalyst, transport molecule, EDTA, PT, PTT

PK also called ______ or _____ is a precursor to _____ which activates ____. it circulates with _____.

prekalikrein, fletcher factor, kalikrein, plasminogen, HMWK

Kalikrein is vitamin K _____ (dependent/independent), activates _____ and _____, and recruits _____.

independent, plasminogen, complement, phagocytes

HMWK also called ______ is a cofactor for the activation of _____ and a cofactor for reactions with factor _____, when activated it leads to ______/ ______

Fitzgerald, factor 7, factor 12, kinin, bradykinin