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Generalized Anxiety Disorder (GAD)
Excessive anxiety and worry, more days than not, for at least 6 months about various situations or activities.
GAD Diagnostic Criteria
Excessive worry for 6 months, difficulty controlling worry, 3 or more associated symptoms, and clinically significant distress or impairment.
GAD Six Symptoms
Restlessness, easily fatigued, difficulty concentrating, irritability, muscle tension, and sleep disturbance.
GAD Minimum Symptoms
3 or more of the 6 associated symptoms.
GAD Duration
At least 6 months.
GAD Comorbidity
Especially major depressive disorder, panic disorder, and social anxiety disorder.
GAD vs. Normal Worry
GAD worries differ in frequency, intensity, and perceived control over worry.
GABA Theory of GAD
Individuals with GAD have decreased GABA activity and less inhibition of threat-activated structures.
GABA
A neurotransmitter that aids inhibition of subcortical circuits stimulated by threat.
GABA Receptor Locations
Frontal cortex, hippocampus, and amygdala.
Benzodiazepines
Facilitate GABA binding and can be effective for GAD.
Cognitive Errors in GAD
Maladaptive assumptions, including probability overestimation and catastrophizing.
Probability Overestimation
Overestimating the likelihood that negative events will occur.
Catastrophizing
Expecting extremely negative consequences from situations.
Attentional Bias
Bias toward threat-related material.
Memory Bias
Bias toward threat-related material in memory.
Sociocultural Perspective of GAD
GAD is more likely to develop in people facing dangerous ongoing social conditions or highly threatened environments.
Societal Stress Factors
Poverty, race and ethnicity-related stressors, and widespread illness.
Avoidance Theory of GAD
Worry is often a verbal or linguistic process that may distract from emotional distress.
Negative Reinforcement of Worry
Worry continues because it temporarily reduces emotional distress.
Intolerance of Uncertainty
Difficulty tolerating uncertainty; changes in intolerance of uncertainty may precede changes in worrying.
Metacognitive Model
Focuses on beliefs about worry, including positive and negative beliefs.
Positive Beliefs About Worry
Belief that worry is helpful.
Negative Beliefs About Worry
Belief that worry is uncontrollable or dangerous.
Meta-Worry
Worry about worry.
CBT for GAD
More effective than wait-list and nonspecific alternatives, with better long-term maintenance and tolerability in comparisons with medication.
First-Line Medication for GAD
Selective serotonin reuptake inhibitors (SSRIs).
Benzodiazepine Risks
Tolerance, dependence, and withdrawal symptoms.
Benzodiazepine Treatment Recommendations
Recommended only for short-term treatment or severe, treatment-resistant GAD.
Specific Phobia
Marked fear or anxiety about a specific object or situation.
Specific Phobia DSM-5-TR Criteria
Immediate fear, avoidance or intense endurance, disproportionate fear, persistence typically at least 6 months, and clinically significant distress or impairment.
Specific Phobia Duration
Typically at least 6 months.
Agoraphobia
Marked fear or anxiety about 2 or more situations because escape or getting help might be difficult.
Five Agoraphobia Situations
Public transportation, open spaces, enclosed places, standing in line or crowds, and being outside the home alone.
Agoraphobia Minimum Situations
2 or more of the 5 specified situations.
Agoraphobia Avoidance
Situations are avoided, require a companion, or are endured with intense fear or anxiety.
Agoraphobia Duration
Typically at least 6 months.
Classical Conditioning
Learning fear through association between stimuli.
Little Albert
Watson and Rayner's 1920 example of classical conditioning of fear.
Observational Learning
Acquiring fear by watching or modeling others.
Negative Reinforcement of Phobic Avoidance
Avoidance continues because escaping a feared situation reduces anxiety.
Preparedness
A behavioral-evolutionary explanation for why certain fears are more readily acquired.
Phobia Treatments
Exposure therapies, modeling, and participant modeling.
Social Anxiety Disorder
Marked anxiety about social situations involving possible scrutiny by others.
Social Anxiety Core Fear
Fear of acting in a way or showing anxiety that will be negatively evaluated.
Social Anxiety DSM-5-TR Criteria
Fear of scrutiny, negative evaluation, avoidance or intense anxiety, disproportionate fear, persistence, and impairment.
Social Anxiety Duration
Typically at least 6 months.
Social Anxiety Treatments
Cognitive therapy, exposure therapy, group therapy, and social skills training.
Panic Disorder
Recurrent unexpected panic attacks followed by persistent concern or maladaptive behavior change.
Panic Attack
An abrupt surge of intense fear or discomfort reaching a peak within minutes.
Panic Attack Minimum Symptoms
4 or more listed symptoms.
Panic Attack Heart and Breathing Symptoms
Palpitations, pounding heart, accelerated heart rate, sweating, trembling, shortness of breath, choking, and chest discomfort.
Other Physical Panic Attack Symptoms
Nausea, dizziness, chills or heat sensations, and numbness or tingling.
Psychological Panic Attack Symptoms
Derealization, depersonalization, fear of losing control, and fear of dying.
Paresthesias
Numbness or tingling sensations.
Panic Disorder One-Month Criterion
At least one attack followed by at least 1 month of persistent worry about attacks or their consequences and/or maladaptive behavior change.
Panic Brain Circuit
Includes the amygdala, hippocampus, hypothalamus, central gray matter, and locus coeruleus.
Cognitive Explanation for Panic Disorder
Misinterpretation of bodily sensations and anxiety sensitivity.
Anxiety Sensitivity
Fear of anxiety-related bodily sensations.
Obsessive-Compulsive Disorder (OCD)
Presence of obsessions, compulsions, or both that are time-consuming or cause clinically significant distress or impairment.
Obsessions
Recurrent and persistent thoughts, urges, or images that are intrusive, unwanted, and may cause anxiety or distress.
Response to Obsessions
Attempts to ignore or suppress intrusive thoughts or neutralize them with another thought or action.
Compulsions
Repetitive behaviors or mental acts performed in response to obsessions or according to rigid rules.
Purpose of Compulsions
To prevent anxiety, distress, or a dreaded event, although the behaviors are excessive or not realistically connected.
OCD Time Criterion
Obsessions or compulsions take more than 1 hour per day or cause clinically significant distress or impairment.
OCD Insight Specifiers
Good or fair insight, poor insight, or absent insight/delusional beliefs.
OCD Tic-Related Specifier
Used when OCD is associated with a tic disorder.
Cognitive-Behavioral Explanations of OCD
Obsessional intrusive thoughts, dysfunctional beliefs, and negative reinforcement of compulsions and avoidance.
Inflated Responsibility
Belief that one has the power to cause or prevent negative outcomes.
Overestimation of Threat
Belief that negative events are likely and would be unmanageable.
Exaggerated Importance of Thoughts
Belief that the mere presence of a thought means it is significant.
Need to Control Thoughts
Belief that complete control over one's thoughts is necessary and possible.
Perfectionism in OCD
Belief that mistakes and imperfection are intolerable.
Intolerance of Uncertainty in OCD
Belief that it is necessary and possible to be 100% certain that negative outcomes will not occur.
Negative Reinforcement of Compulsions
Compulsions and avoidance continue because they temporarily reduce anxiety or distress.
OCD Identical Twin Concordance
Approximately 53%.
OCD Fraternal Twin Concordance
Approximately 23%.
OCD Neurobiological Models
Genetics, abnormal serotonin activity, and brain circuit abnormalities.
OCD Neurotransmitters
Serotonin, with possible involvement of glutamate, GABA, and dopamine.
OCD Medication
SSRIs.
OCD Psychotherapy
Cognitive-behavioral therapy, exposure and response prevention, and cognitive therapy.
Exposure and Response Prevention (ERP)
A CBT treatment involving exposure to feared stimuli while preventing compulsive responses.
OCD-Related Disorders
Body dysmorphic disorder, hoarding disorder, trichotillomania, and excoriation disorder.
Body Dysmorphic Disorder
An obsessive-compulsive-related disorder involving preoccupation with perceived appearance flaws.
Hoarding Disorder
An obsessive-compulsive-related disorder involving persistent difficulty discarding possessions.
Trichotillomania
Hair-pulling disorder.
Excoriation Disorder
Skin-picking disorder.
Acute Stress Disorder
Trauma-related symptoms persisting for 3 days to 1 month after trauma.
Posttraumatic Stress Disorder (PTSD)
Trauma-related symptoms lasting more than 1 month and causing significant distress or impairment.
PTSD Qualifying Trauma
Exposure to actual or threatened death, serious injury, or sexual violence.
PTSD Four Exposure Routes
Direct experience, witnessing, learning about trauma to a close family member or friend, or repeated or extreme exposure to aversive details.
PTSD Four Symptom Clusters
Intrusion, avoidance, changes in cognition or mood, and changes in arousal or reactivity.
PTSD Intrusion Symptoms
Intrusive memories, dreams, and flashbacks related to the traumatic event.
PTSD Avoidance
Persistent avoidance of stimuli associated with the traumatic event.
PTSD Duration
More than 1 month.
PTSD Dissociative Specifier
Persistent or recurrent depersonalization or derealization.
Depersonalization
Feeling detached from oneself.
Derealization
Feeling that surroundings are unreal.
PTSD Delayed Expression
Full diagnostic criteria are not met until at least 6 months after the trauma.
PTSD Projected U.S. Lifetime Risk
8.7% according to the lecture slides.