Peptidoglycan

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Last updated 3:48 PM on 9/18/25
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10 Terms

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Peptidoglycan

polysaccharide composed of two sugars and crosslinking amino acids

2
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Polysaccharides

  • N-acetylglucosamine (NAG)
  • M-acetylmuramic acid (NAM)
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Polypeptide (Amino Acids)

  • Alanine
  • Glutamic Acid
  • Lysine (G+) or Diaminopimelic Acid (DAP) (G-)
  • Alanine
  • Glycine bridge (G+ only)
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B 1,4 Bonds

  • connect NAG and NAM
  • rigidity and strength in X direction
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Gram Positive

  • glycine bridge between Ala and Lys
  • extensive crosslinking
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Gram Negative

cross link between DAP and Ala

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Gram Positive Cell Wall

  • thick peptidoglycan
  • includes teichoic acid and lipoteichoic acid
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Gram Negative Cell Wall

  • lipopolysaccharide (LPS) layer: endotoxin that induces inflammation during infection
  • true periplasmic space between LPS and peptidoglycan layer
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LPS Layer

outer lipid bilayer containing LPS and toxic portion called lipid A

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Archaea

  • peptidoglycan absent in Archaea
  • pseudomurein present instead