Peptidoglycan
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10 Terms
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Peptidoglycan
polysaccharide composed of two sugars and crosslinking amino acids
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Polysaccharides
- N-acetylglucosamine (NAG)
- M-acetylmuramic acid (NAM)
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Polypeptide (Amino Acids)
- Alanine
- Glutamic Acid
- Lysine (G+) or Diaminopimelic Acid (DAP) (G-)
- Alanine
- Glycine bridge (G+ only)
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B 1,4 Bonds
- connect NAG and NAM
- rigidity and strength in X direction
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Gram Positive
- glycine bridge between Ala and Lys
- extensive crosslinking
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Gram Negative
cross link between DAP and Ala
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Gram Positive Cell Wall
- thick peptidoglycan
- includes teichoic acid and lipoteichoic acid
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Gram Negative Cell Wall
- lipopolysaccharide (LPS) layer: endotoxin that induces inflammation during infection
- true periplasmic space between LPS and peptidoglycan layer
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LPS Layer
outer lipid bilayer containing LPS and toxic portion called lipid A
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Archaea
- peptidoglycan absent in Archaea
- pseudomurein present instead
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