FINALS: Intro to Malignancies (5)

Below-normal serum EPO level

Which is a minor criterion for PV?

Arterial and venous vascular accidents

Which is a serious complication of PV?

• Thrombophlebitis with pulmonary embolism

• Transition to acute leukemia

• Increased blood volume

PV may be complicated by:

Reactive erythrocytosis due to hypoxia

The main differential diagnosis of PV mentioned in the lecture is:

Leukocytosis and thrombocytosis

Which blood finding may occur in PV?

Normal or increased

The leukocyte alkaline phosphatase (LAP) score in PV is generally:

• Splenomegaly

• Hepatomegaly

Which organ enlargement may be observed in PV?

Bone marrow fibrosis and extramedullary hematopoiesis

Primary myelofibrosis (PMF) is characterized by:

• JAK2

• CALR

• MPL

Which mutation may be found in PMF (Primary myelofibrosis)?

Dacryocytes (tear-drop cells)

Which blood smear finding is characteristic of PMF (Primary myelofibrosis)?

• Leukoerythroblastosis

• Anisocytosis

• Poikilocytosis

PMF may produce which peripheral blood picture?

Collagen and reticulin fibers

Fibrosis in PMF is associated with increased:

• Splenomegaly

• Hepatomegaly

Which clinical finding is common in PMF?

Splenic involvement and progression to acute leukemia

In PMF, increased CD34+ cells may be associated with:

Leukemic transformation is a common cause of death

Which may be a cause of death in PMF?

Megakaryocytic proliferation and atypia with grade 2 or 3 fibrosis

Which is a major criterion for overt PMF?

• JAK2

• CALR

• MPL

Which mutation is included in PMF diagnostic criteria?

• Anemia

• Leukocytosis

• Splenomegaly

Which is a minor criterion for PMF?

• Increased LDH

• Leukoerythroblastosis

• Anemia

Which laboratory finding may support PMF diagnosis?

• Infiltrative malignancies

• Infections

• Chemical toxins or irradiation

Secondary myelofibrosis may result from:

Sustained thrombocytosis

Essential thrombocythemia (ET) is characterized by:

450,000/µL or greater

The platelet count threshold in WHO criteria for ET is:

• JAK2

• CALR

• MPL

Which mutation may be found in ET?

Megakaryocytic proliferation

Bone marrow in ET typically shows:

• Giant bizarre platelets

• Platelet aggregates

• Megakaryocyte fragments

Which platelet morphology may be observed in ET?