Chpt 10: Reproductive hormone drugs

What does CIDR mean?

Controlled Internal drug release

What does Gravid mean?

pregnant

What glands do reproduction start with?

Hypothalamus and pituaitary gland

What hormone does the Hypothalamus produce?

Gonadotropin releasing hormone

Gonadotropin releasing hormone stiulayes the pituiaotry gland to release?

Follicle stimulating hormone (FSH), Luteinizing hormone (LH)

Where follicle stimulating hormone produced?

Anterior pituitary gland

Where is the site of action for follicle stimulating hormone?

Ovary/testes

What does follicle stimulating hormone stimulate in females?

Oogensis, growth and development of follicles/mature eggs

What do Follicle stimulating hormone stimulate in males?

Stimulates spermatogenesis- production of sperm

What is spermatogenesis?

production of sperm

What is Oogensis?

Growth and development of eggs

What hormone does the hypothalamus produce o stimulate the anterior pituitary gland to produce and release FSH and LH?

Gonadotropin releasing hormone

Where is the site of action of lutenizing hormone on females?

Ovaries, follicle

Where is the site of action of lutenizing hormone on males?

Testes

What are two male hormone-like drugs?

Androgens, Testosterone

What is the primary male sex hormone?

Testosterone

What effects does testosterone have?

Anabolic effects, Androgenic effects

What are anabolic effects of testosterone?

tissue building

What are androgenic effects of testosterone?

promotes male characteristics

What are male hormone like drugs (adrogens, testosterone) used for?

Teaser animals. promote growth, prevent estrus, Tx for flase pregnancies

What is an example of a specieific drug that provides testosterone and estradoil to promote growth in cattle?

Synovex H and EH implants

Where is estrogen produced?

Ovaries, testicles, adrenal cortex, placenta

What is the function of estrogens in a females body?

promote female sex characteristics, stimulate reproductive function

What is an example of an estrogen like drug?

DES (diethystilbestrol)

What are estrogen medications used to treat?

urinary incontinence in spayed females dogs, vaginitisis, and to manipulate estrus cycle

What are side effects of giving estrogen drugs?

bone marrow suppression, endometrial hyperplasia, follicular cysts, pyometr

Who should not handle any hormone like drug?

pregnant women

What is an FDA-CVM approved for Tx of estrogen responsive urinary leakasge/incontience in spayed dogs?

Estriol

What is a risk of using Estriol?

anorexia, vomiting, swollen vulva, mammary hyperplasia

Why would estrogens cause a risk of pyometra in intact females?

Causes endometrial hyperplasia, increase secretions, can cause cysts on ovaries (high levels of estrogen)

What is the Female sex hormone produced and secreted by Corpus Luteum (CL) after ovulation?

Progesterone

What are functions of progesterone?

Maintains pregnancy (‘pro’ gestation), inhibits estrus and ovulation

When might you used progesterone?

To match up cycles in females to know when you can breed them

What do all progesterone drugs have in them?

GEST

What are 4 examples of progesterone drugs?

Altrogenogest, progesterone, megestrol acetate, melengestrol acetate

What does Altrogenogest do?

FDA approved oral and injectable, used in horses to suppress estrus, for estrus synch, and to maintain pregnancy in mares 

What does progesterone do?

intravaginal insert for cattle and sheep, extended release of progesterone for estrus synch

What does megestrol acetate do?

oral tablets used in small dogs to postpone estrus, alleviate false pregnancies

What does melengestrol acetate do?

synthetic form of progesterone added to feed to suppress estrus in feedlot heifers, improve growth, improve feed efficiency

Which male hormone is used to create teaser (altered) animals that are used to detect heat in females (livestock) and to prevent estrus in female dogs not intended for breeding or for treatment of false pregnancies?

Testosterone

Which female hormone is used to treat urinary incontinence and has side effects of bone marrow suppression and risk of pyometra?

Estrogen - estradial

What are 2 ways in which progesterones are used to manipulate the estrus cycle in cattle?

Estrus sync programs, supress estrus