BMED 5207 endocytosis of LDL receptor via clathrin coated pits(exam 3)

0.0(0)
Studied by 0 people
call kaiCall Kai
learnLearn
examPractice Test
spaced repetitionSpaced Repetition
heart puzzleMatch
flashcardsFlashcards
GameKnowt Play
Card Sorting

1/8

encourage image

There's no tags or description

Looks like no tags are added yet.

9 Terms

1
New cards

step 1: endocytosis of LDL receptor

LDLR is recruited to the clathrin coated pits through its interaction with an accessory adaptor protein AP-2 and clathrin. Clathrin coated vesicles are formed. ARF protiens are not needed for this process

2
New cards

step 2: endocytosis of LDL receptor

after uncoating, endocytic vesicles bind Rab5-GTP

3
New cards

step 3: endocytosis of LDL receptor

RAB5-GTP binds PI(3)P

4
New cards

step 4: endocytosis of LDL receptor

Rab5-GTP and PI(3)P bind EEA1 to tether the vesicle to another endocytic vesicle or the early endosome

5
New cards

step 5: endocytosis of LDL receptor

v-snare—t-snare mediated fusion

6
New cards

step 6: endocytosis of LDL receptor

in the low pH environment of the early endosome, LDL and its receptor dissociate

7
New cards

step 7: endocytosis of LDL receptor

LDLR is recycled to the plasma membrane

8
New cards

step 8: endocytosis of LDL receptor

the early endosome matures into late endosome

9
New cards

step 9: endocytosis of LDL receptor

the late endosome fuses with the lysosome