W3L2: Non-Visual Photoreceptors

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Last updated 9:46 PM on 10/18/26
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5 Terms

1
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What is a circadian rhythm?

24hr variations in physiology and behaviour which persist in the absence of any cyclic cue from the environment

2
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Describe the range of light in which rods are active

  • Go from completely depolarised to completely hyperpolarised

  • Useful up to the low twilight range (i.e. 1000x stronger than darkness)

    • Become fully saturated in light brighter than twilight


3
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Describe the range of light in which cones are active

  • Go from fully depolarised to fully hyperpolarised

  • Large overlap w/ rod activity


4
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What is GCAP? Describe its role in relation to cGMP

  • Guanylyl Cyclase Activating Protein

  • Activates Gyanylyl Cyclase

  • GC activates cGMP


5
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State the signalling cascade for melanopsin

  1. Melanopsin activate G-protein Gq/11

  2. Gq/11 activate phospholipase C (effector enzyme)

  3. Phospholipase C cause changes in IP3 & DAG (second messengers)

  4. Open effector TRPC cation channel → depolarisation