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Neuroplasticity
The brain’s ability to change/adapt by developing new or alternative neural pathways from existing neurons
Severed neurons
Do NOT reconnect, can result in permanent loss of features, or movement, the brain CAN adapt
Cerebral cortex is divided into two halves called
Hemispheres
Frontal lobe
Located at front of the brain
Functions: Thinking, planning, decision-making, speaking, voluntary movement
Damage causes: Change in personality, poor planning, impulsive behavior, difficulty making decisions, problems with attention, impaired voluntary movement/speech
Parietal lobe
Located at top/back of brain
Functions: Touch, body sensations, spatial awareness
Damage causes: Difficulties perceiving touch, failure to recognize objects by touch/recognizing one’s body, phantom limb pain, hemi-spatial neglect
Occipital lobe
Located at back of brain
Function: Processes visual information
Damage causes: Hallucinating, blindness, inability to see color, motion, or orientation-synesthesia
Temporal lobe
Located at sides of brain
Functions: Hearing, memory, language
Damage causes: Difficulties in understanding speech, faces, and objects, inability to attend to sensory input, persistent talking, long-short term memory loss
Motor cortex
Located at rear of frontal lobe (in front of sensory cortex!)
Function: Controls voluntary movement
Damage causes: Speech impairment, distortions of body image, motor-learning deficits
Sensory cortex (somatosensory)
Located at the front of parietal lobe (behind motor cortex!)
Functions: Processes sensations from the body (ex: touch)
Damage causes: Same as parietal lobe
Cerebral cortex
Functions: Thinking, learning, remembering, speaking, connecting information
Association Areas = higher thinking
Outermost layer of brain made up of cell bodies of neurons called gray matter
Damage causes: Impaired perception, recognition, motor planning, and higher cognitive functions
Thalamus
Acts as a sensory relay station, it sends incoming sensory information to appropriate areas of the brain
Damage causes: Amnesia, apathy, coma, dementia, difficulty speaking, loss of alertness & activation, sleepiness, damage to Broca’s area
Hypothalamus
Helps maintain homeostasis, it helps control hunger, thirst, body temperature, hormones, emotion, and reward
Damage causes: Aggression, chronic stress, hypothermia, hypersomnia, lethargy, self-mutilation, weight gain/loss, over/under stress drive
Hippocampus
Helps process explicit conscious memories
Damage causes: Severe memory impairment and disorientation
Amygdala
Involved in emotional responses, especially fear and aggression
Damage causes: Aggression, irritability, loss of control of emotion, disruption of short-term memory, deficits in recognizing emotions (particularly fear)
Pituitary gland
Helps control the body’s endocrine system by balancing hormones, gets input and is controlled by hypothalamus
Damage causes: Disrupt in hormone production, leading to widespread health issues, including fatigue, growth problems, metabolic disturbances, and life-threatening adrenal crises
Brainstem
Function: Controls many automatic survival functions
Damage causes: Respiratory failure, cardiovascular instability, loss of consciousness, paralysis, or even death
Medulla
Function: Controls important automatic functions like heartbeat and breathing
Damage causes: Injury or disease may cause numbness, paralysis, difficulty swallowing, acid reflux, lack of movement control, overall damage can be fatal
Pons
Function: Sleep, movement, coordination
Damage causes: Impaired breathing, deafness, paralysis, sleep disturbance, loss of taste
Reticular formayion
Function: Arousal, alertness, attention
Damage causes: Fatigue, changes in sexual arousal, disrupted sleep patterns, severe damage typically results in coma/death
Cerebellum
Located at back of brainstem
Functions: Balance, coordination, voluntary movement, some learning and memory
Damage causes: Loss of coordination, tremor, inability to walk, dizziness, slurred speech
Forebrain
Function: Controls many complex functions
Includes: Cerebral cortex, limbic system, thalamus, hypothalamus
Midbrain
Function: Connects the hindbrain and forebrain
Involves: Movement, seeing, hearing
Hindbrain
Function: Survival and coordination
Includes: Medulla, pons cerebellum
Corpus Callosum
Bundle of axons located at deep midline, beneath cerebral cortex
Function: Main structure that connects brain’s hemispheres, ensuring communication
Limbic system
Network of interconnected brain structures that regulates emotion, behavior, motivation, memory, and autonomic functions
Amygdala, hippocampus, hypothalamus (AHH or HAH)
Prefrontal cortex
A specialized AREA (not lobe!!!!) at the very front of the frontal lobe, responsible for higher-order cognitive functions
Nucleus Accumbens
Plays a role in the reward centers of the brain
Located in the midbrain AND forebrain, this area is responsible for smooth voluntary body movements and posture.
Basal Ganglia
This association area in parietal lobes is related to language – specifically translating visual info (e.g. words on a page) from occipital lobe into code that is sent to Wernicke’s area where it is understood as language.
Angular Gyrus
Broca’s area
Region in left frontal lobe responsible for speech production, grammatical processing, and motor planning for articulation
Damage causes: Production of speech is non-fluent/effortful, repetition impaired but comprehension preserved, usually aware of mistakes
Wernicke’s area
Region in left temporal lobe responsible for language comprehension
Damage causes: Production of speech is fluent but meaningless, comprehension and repetition is impaired, usually unaware of mistakes
Which lobe holds the ability to recognize faces/also involved in auditory processing?
Temporal
Which lobe is responsible for being able to see written words as visual stimulations?
Occipital
Which brain structure makes sure all incoming sensory information (EXCEPT SMELL) is sent to the correct cortex for processing?
Thalamus - located in forebrain region
Structure most responsible for balance, coordinating motor movement, and processing memories?
Cerebellum - located in hindbrain
Which structure is responsible for feeding, fighting, fleeing, flirting, and Fahrenheit?
Hypothalamus - part of limbic system
Which area of the brain controls sleep and dreaming?
Pons - located in hindbrain (brainstem)
Which area controls emotions such as fear, aggression, and rage?
Amygdala - located in forebrain/limbic system
Which area receives sensory input for touch, pain, temperature, and body position?
sensory cortex - located in parietal lobe
Area responsible for impulse control
Frontal lobe
What is the term for the places on cerebral cortex that are not dedicated to either sensory or motor functions?
Association areas
Area of brain responsible for automatic survival reflexes such as coughing, sneezing, and vomiting?
Medulla
Area of brain related to arousal to stimuli?
RAS/Reticular Formation - *if damaged can result in coma or death*
Which lobe is responsible for muscle movement?
Frontal
Oldest and innermost part of the brain
Hindbrain/brainstem
Area responsible for reasoning, planning, and judgement
Prefrontal cortex
Which area holds information regarding procedural memory or “how to” memories?
Cerebellum
Inner layer of brain made up of the axons of neurons and glial cells, is called white matter, it does not include brainstem or cerebellum
Cerebrum - responsible for conscious thought, sensory processing, language, memory, and voluntary movement. Includes cerebral cortex, white matter, and subcortical structures such as the hippocampus and basal ganglia.
This area is responsible for creating new memories and is related to learning
Hippocampus - located in limbic system/forebrain
Damage to one of these areas may result in aphasia (problem with understanding or articulating speech)
Wernicke’s area or Broca’s area
Which part of the brain is involved in triggering involuntary (sympathetic nervous system) aspects of fight or flight?
Hypothalamus
This area is sometimes cut in patients with severe epilepsy to prevent epilepsy from damaging both hemispheres of the brain
Corpus callosum
This area is activated when listening/humming a tune
Primary Auditory Cortex in Temporal Lobes
This area is responsible for filtering incoming information and sending along relevant information to the thalamus
RAS/Reticular formation
Which neurotransmitters are most closely associated with mood?
Serotonin & Norepinephrine
An excess of this neurotransmitter is most closely associated with schizophrenia
Dopamine
Which neurotransmitter is closely associated with pain relief?
Endorphins
Which neurotransmitter is most closely associated with voluntary motor movement and pleasure?
Dopamine
Which neurotransmitter is most closely associated with memory and involuntary movement?
Acetylcholine
Low levels of this neurotransmitter are associated with Parkinson’s disease
Dopamine
Which neurotransmitters are closely associated with memory losses of Alzheimer’s disease when these cells die?
Acetylcholine
Which neurotransmitter is released to indicated pain?
Substance P
Agonists
Increase neural transmission - mimic natural neurotransmitters
Antagonists
Reduces neural transmission - blocks neurotransmitters
Low levels of this neurotransmitter are linked to anxiety
GABA
Which neurotransmitter in HIGH levels is associated with the mania phase of bipolar disorder?
Norepinephrine
Heroin users receive a rush of pleasure causing ______, but the drug also works as an agonist for the natural pain-relieving neurotransmitter ______
Dopamine; Endorphins
Which neurotransmitter is associated with mood is also a hormone?
Norepinephrine
These cells comprise about 50% of the brain’s total volume; provide nourishment, protection, and insulation for neurons
Glial cells
Sensory Neurons are also called
Afferent neurons
Motor neurons are also called
Efferent neurons
What is the overall charge of the interior of the resting neuron?
-70mv
What do we call the minimum amount of excitatory neurotransmitters received by the dendrites of a postsynaptic neuron that is require for the cell to fire
Threshold
What is the name for the resting pause that occurs after an action potential where the excess positively charged sodium is pumped out of the axon? During this time the neuron cannot fire.
Refractory period
The brain technique measures the electrical activity of neurons below electrodes that are placed on the scalp
EEG - function
This brain imaging technique involves taking several X-rays from many angles and combining them to create a detailed image of the brain
CT scan - structure
This brain imaging technique begins with the injection of a small harmless amount of radioactive material such as glucose into the bloodstream. This scan produces color-coded images that indicate areas of brain activity during cognitive or motor tasks
PET scan - function
This brain imaging technique uses magnetic fields, radio waves, and computer-based enhancement to create detailed 3d high resolution pictures of the brain
MRI - structure
This brain imaging technique uses magnetic fields and measures blood flow that carries oxygen to active brain tissues
fMRI - both structure and function