schizophrenia treatment

1st gen (atypical) antipsychotics include

• haloperidol

• perphenazine

• fluphenazine

• chlorpromazine

1st gen is for

treating/decreasing psychosis and anxiety

1st gen class

dopamine antagonist

1st gen target

positive symptoms

1st gen disadvantages

• extrapyramidal side effects

• anticholinergic effects

• tardive dyskinesia

• weight gain

• sexual dysfunction

• endocrine disturbances

extrapyramidal interventions

• call provider for dose to be lowered

• other antipsychotic considered

• antiparkinson drug before starting (benztropine, diphenhydramine)

tardive dyskinesia interventions

• Abnormal Involuntary Movement Scale (AIMS) measures severity

• persistant eps

• from prolonged use, might no stop

2nd gen (atypical) antipsychotics include

• olanzapine

• quetiapine

• clozapine

• aripiprazole

• risperidone

2nd gen are for

agitation/emergency

2nd gen treat

both negative and positive symptoms

2nd gen have minimal

to no EPS/tardive symptoms

2nd gen causes

significant weight increase, metabolic syndrome

2nd gen interventions

monitor labs

• heart, kidney

• myocarditis risk

antipsychotic risks

• neuroleptic malignant syndrome

• decrease neutrophil count with clozapine

  • monitor infection signs

• prolonged qt interveral

• liver impairment