Antibiotic LC

amox/clav

B: Augmentin

amox/clav class

penicillin + B- lactamase inhibitor

amox/clav indication

CAP/sinusitis/otitis/UTI

amox/clav pathogens

Staphylococcus aureus, streptococcus pneumoniae, E. coli, Haemophilus influenzane, moraxella catarrhalis

amox/clav dose

875mg po q12h

amox/clav adjustments

r and h: yes

amox/clav ADR

Gi/hepatic: hepatotocxicity (LFTs)

ampicillin/sulbactam

B: unasyn

ampicillin/sulbactam class

penicillin + B-lactamase inhibitor

ampicillin/sulbactam indication

intra-abdominal/skin infections

ampicillin/sulbactam pathogens

enterococcus faecalis, E.coli, klebsiella pneumoniae

ampicillin/sulbactam dose

3g IV q6h

ampicillin/sulbactam adjustments

r: yes and h: no

ampicillin/sulbactam ADR

hem/immunologic: anaphylaxis (m: hypersensitivity)

azithromycin

B: Zithromax

azithromycin class

macrolide

azithromycin indication

community acquired pneumonia

azithromycin pathogens

haemophilus influenzae, moraxella catarrhalis, mycoplasma pneumoniae

azithromycin dose

500mg day 1 then 250 mg qd

azithromycin adjustments

r and h: no

azithromycin ADR

Cv: QT prolongation (m: ECG)

Aztreonam

B: azactam

Aztreonam class

monobactam

Aztreonam indication

gram neg infections

Aztreonam pathogens

pseudomonas aeruginosa, E. coli, Klebsiella pneumoniae

Aztreonam dose

2g IV q8h

Aztreonam adjustments

r: yes and h: no

Aztreonam ADR

hem/immunologic: hypersensitivity (m: CBC)

cefepime

B: maxipime

cefepime class

4th gen cephalosporin

cefepime indication

HAP/febrile neutropenia

cefepime pathogens

Pseudomonas aeruginosa, enterobacter cloacae, E. coli

cefepime dose

2g IV q8h

cefepime adjustments

r: yes and h: no

cefepime ADR

neuro/sensory: neurotoxicity (m: mental status)

ceftaroline

B: teflaro

ceftaroline class

5th gen cephalosporin

ceftaroline indication

CAP/ABSSSI

ceftaroline pathogens

MRSA, street pneumoniae

ceftaroline dose

600mg IV q12h

ceftaroline adjustments

r: yes and h: no

ceftaroline ADR

hem/immunologic: hypersensitivity (m: monitor reaction)

ceftriaxone

B: rocephin

ceftriaxone class

3rd gen cephalosporin

ceftriaxone indication

CAP/ meningitis

ceftriaxone pathogens

neisseria gonorrhoeae, strep pneumoniae, E. coli

ceftriaxone dose

2g IV q24h

ceftriaxone adjustments

r and h: no

ceftriaxone ADR

GI/hepatic: biliary sludging (m: LFTs)

imipenem/cilastatin

B: primaxin

imipenem/cilastatin class

carbapenem

imipenem/cilastatin indication

severe polymicrobial infection

imipenem/cilastatin pathogens

pseudomonas aeruginosa enterobacterales

imipenem/cilastatin dose

500mg IV q6h

imipenem/cilastatin adjustments

r: yes and h: no

imipenem/cilastatin ADR

neuro/sensory: seizures (m: neurological status)

levofloxacin

B: Levaquin

levofloxacin class

fluoroquinolone

levofloxacin indication

CAP/UTI

levofloxacin pathogens

street pneumoniae, pseudomonas aeruginosa

levofloxacin dose

750mg qd

levofloxacin adjustments

r: yes and h: no

levofloxacin ADR

bone/joint/muscle: tendon rupture (m: tendon pain)

meropenem

B: merrem

meropenem class

carbapenem

meropenem indication

complicated intra abdominal infection

meropenem pathogen

pseudomonas aeruginosa and ESBL enterobacterales

meropenem dose

1g IV q8h

meropenem adjustments

r: yes and h: no

meropenem ADR

neuro/sensory: seizures (m: neurological status)

piperacillin/tazobactam

B: zosyn

piperacillin/tazobactam class

penicillin + B-lactamase inhibitor

piperacillin/tazobactam indication

HAP/ intra abdominal infection

piperacillin/tazobactam pathogens

pseudomonas aeruginosa, bacteroides fragilis, E. coli

piperacillin/tazobactam dose

4.5g IV q6h

piperacillin/tazobactam adjustments

r: yes and h: no

piperacillin/tazobactam ADR

renal/GU: nephrotoxicity (m: SCr)

vancomycin

B: vancocin

vancomycin class

glycopeptide

vancomycin indication

MRSA infections

vancomycin pathogens

MRSA enteroccus faecalis, and C.diff (PO)

vancomycin dose

15-20mg/kg IV q8-12h

vancomycin adjustments

r: yes and h: no

vancomycin ADR

renal/GU: nephrotoxicity (m: SCr + AUC)