pseudomonas aeruginosa

this organism is gram negative, facultative anaerobic, motile, bacilli

p. aeruginosa

what pigment does p aeruginosa hae

pyocyanin

this is an autosomal recessive disorder with defect on cftr channel which affects flow of cl- ions

cystic fibrosis

what happens in cf lung

thick mucus

what has p. aeruginosa had resistance against sine 2011

carbapenems

what are virulence factors in the acute phase of infection

type 3 and 6 secretion

in the chronic aeruginosa infection what are some virulence switches made from acute

lps deficiency, alginate production, biofilms, non-motile, antibiotic resistance

this acute phase factor solubilizes phospholipids

phosphilopase

this acute phase factor cuts elastin in lung and degrades antibodies

elastase

this acute phase factor adp ribosylates EEF2 which blocks protein synthesis

exotoxin A

this effector of type 3 secretion is an acute cytotoxin (phospholipase)

exoU

these type 3 effectors cause actin cytoskeleton disruption and blocks phagocytosis of organism and induce cell death

exot, s, y

this system kills of competition when they are attacked by them

type 6 secretion

this arises in infection with chronically colonized patients lik cystic fibrosis, usually in genes involved in mutation repair

hyper-mutators

in CF and lung infections with aeruginosa, what is usually produced which causes onset of progressive lung deteriortion

alginate

what are two effects of alginate overproduction

increased antibiotic resistance and protection against host immune responses

what is the factor which controls expression of alginate synthetic operon

algU

what sequesters algU at the membrane in acute strains when alginate synthesis is off

mucA

In chronic strains, algU is released from a truncated much which causes what

alginate expression