BIOL 5500 - Case Studies in T Cell Development

Mutations in what other molecule associated with MHC class I expression might account for diminished or no MHC class present?

TAP

How is cell-mediated immunity tested?

Delayed Hypersensitivity Skin Tests (DTH)

DTH Skin Tests tests which T Cells?

CD4+ T Cells

When T cells respond normally when stimulated with allogenic B Cells this means what?

Can activate CD8+ T Cells

Why are immunoglobulin levels low when MHC Class Ii is gone?

CD4 is important for making antibodies

Which MHC Class is deficient due to not expressing HLA-DQ or HLA-DR?

MHC Class II

What do you think could cause loss of HLA-DP, -DQ, and –DR?

CIITA Deficiency

What group of cells mediates negative selection in the thymus?

Dendritic cells and macrophages

What will cause a double negative thymocyte to become a double positive?

Successful testing of the Pre-TCR

What happens to γδ T cells after they successfully rearrange and express a functional receptor?

They exit the thymus and enter the circulation