histone marks

bro idek

H3K4 association

active promoters; sits on unmethylated CpG islands; one half of bivalent domain

H3K4me3 reader/key protein

BPTF (NURF; active chromatin remodeling) and ING2 (can recruit a repressive HDAC complex)

H3K4me1 association

active regulatory regions (enhancers)

H3K4me1 reader/key protein

WDR5

H3K27ac association

active promoters and enhancers; activation

H3K27ac reader/key protein

bromodomain proteins

H3K27me3 association

repression; facultative heterochromatin, inactive X, HOX genes; half of bivalent domain

H3K27me3 reader/key protein

polycomb (PC2)

H3K9me3 association

repression; constitutive heterochromatin; exception —> coding region of active genes

H3K9me3 reader/key protein

HP1 (chromodomain)

H3K9ac association

active chromatin; higher at the GR promoter in high-LG offspring (weaver paper)

H3K9ac reader/key protein

bromodomains; removed by HDACs

H3S10ph association

mitotic condensation; activation of immediate-early genes; displaces HP1 from H3K9me3

H3S10ph reader/key protein

14-3-3

H3K56ac location in nucleosome

DNA entry-exit site

H3K56ac association

DNA “breathing” without collapse

marks at dyad axis

H3K64ac, H3K122ac, H3T118ph

H3K64ac, H3K122ac, H3T118ph association

strong destabilization and eviction; active promoters

H4K91ac location in nucleosome

histone-histone interface

H4K91 association

destabilizes octamer; replication/assembly

H3K79me location in nucleosome

outer surface of histone-histone interface

H3K79me association

active transcription; creates a docking site (53BP1/Crb2)

active residues for methylation

H3K4, H3K36, H3K79

repressive residues for methylation

H3K9, H3K27, H4K20