Meds for Pharm Quiz 2

Methotrexate

blocks folate reductase, effects all cells, suspended in S phase

Cyclophosphamide

alkylating agent, prevents DNA separation and replication, cell cycle non-specific

Cisplatin

platinum agent, prevents DNA separation, cell cycle non-specific

Doxorubicin

inserts self between DNA blocking topoisomerase II, prevents DNA replication

Anastrazole

aromatase inhibitor, prevents estrogen formation

Demeclocycline

prevents ADH action at kidneys, tetracycline abx, corrects dilutional hyponatremia

Desmopressin (DDVAP)

synthetic ADH

3% NaCl

corrects severe, symptomatic hyponatremia, slow IV admin

Levothyroxine

synthetic T4, long ½ life, predictable levels

PTU

thionamide, blocks thyroid peroxidase that makes thyroid hormones, preferred in thyroid storm

Methimazole

thionamides, blocks thyroid peroxidase that makes thyroid hormones

Tacrolimus

immunosuppressant, blocks clacineurin so Tcells can’t make IL-2 , Tcells don’t proliferate

Infliximab

immunosup, binds and neutralizes tumor necrosis factor

Tocilizumab

immunosuppressant, blocks receptor for IL-6 cytokine, blocks infection markers (Fever, C-reactive protein)

AntiHistamines (1st Gen)

blocks H1 receptor so histamine can’t send signal

Mitoxantrone

immunosup, broad suppression of beta cells, Tcells & macrophages

Mycophenolate (CellCept)

immunosup, blocks enzyme that T & B lymphocytes depends on to build DNA, lymphocytes cannot proliferate, selective, less bone marrow toxicity