COX 2 INHIBITORS pharm cards

how do cox 2 inhibitors work

they impede the production of the chemical messengers or "prostaglandins" that cause pain and swelling

generic meds

celecoxib (Celebrex)

refexocib

valdecexib

who needs COX 2 INHIBITORS

pts w moderate to severe inflammation

pts with arthritis

who should not use COX 2 INHIBITORS

pts at risk for blood clotting

history of ischemic strokes

history of bleeding problems

side effects of cox 2 inihibitors

mild gi upset

edema

flu like symptoms

nasuea

dizziness

fatal side effects

heart attack

heart failure

stroke

rn implications

WATCH FOR CARDIAC CHANGES

monitor GI, skin rashes, etc

assess ROM

assess affect joints

Selective COX-2 inhibitors cause less GI distress but have

HUGE cardiovascular effects

pt education

take as needed

watch for bleeding and irregular HR, GI upset

notify provider if this happens

edema

rash

weight gain

s/s gi toxicity