Glycolysis enzymes to memroize + domains + criteria for second messengers

Step 1

Hexokinase

Step 2

Phosphohexonse isomerase

Step 3

Phosphofructose kinase 1 (PFK1)

Step 4

Aldolase

Step 5

Triose phosphate isomerase

Step 6

Glyceraldehyde 3-phosphate dehydrogenase

Step 7

Phospho-glycerate Kinase

Step 8

Phospho-glycerate mutase

Step 9

Enolase

Step 10

Pyruvate kinase

SH2

pTyr peptide have binding domain

PTB

pTyr binding domain

WW

2 TRP + binds to proline peptides

SH3

Binds to proline helices

PDZ

Binds to the C-term of other proteins

PH

Binds to PI lipids in membrace

FYVE

Binds to phospholedyinosital-3-p in membrace

1 Criteria for second messenger

Made readily sythesized on demand not stored Ex: ATP- cAMP from AC

2 Criteria for second messenger

Rapidly able to deactivate and stored in specific compartments

3 Criteria for second messenger

Must activate a completely different target protein than the enzyme that created it so it can cannot regulate its own production

4 Criteria for second messenger

Signal Amplification

5 Criteria for second messenger

When hormone binds the enzyme their has to be a response by the secondary messenger

6 Criteria for second messenger

Timing is everything the secondary messenger comes before the effect of the target protein for example cAMP turns on glycogen not vice versa

7 Criteria for second messenger

If block the blockers of the secondary messengers then the signal should stay on longer and stronger

8 Criteria for second messenger

Make sure the second messenger delivers the command and you don’t need an hormone Ex: if you inject dcAMP it should have the same effect as if epinephrine