Proteolysis-chelation theory (onting enzymatic)

Schatz (1955)

mineral structure

organic

enzymatic attack

organic

demineralization

substances

endogenously

degradation

organic

complex calcium

• _________________ looked upon enamel, not as a ________________, but as being essentially __________, like bone and dentin.

  
  

  suggests the involvement of two actions which are interrelated actions:

1. firstly an ___________________ on _____________ constituents

2. followed by a more or less simultaneous __________________ brought about by ____________ arising ________________ from the ______________ of the ____________ constituents; these being able to ____________________

bacterial

organic components

chelating properties

minerals

neutral/alkaline pH

Mucopolysaccharides, lipids and citrates

Schatz

microbial degradation

proteolysis

dissolution

inorganic part

chelation

• ____________ destruction of _____________________of enamel and the breakdown products of these organic components to have _________________and thereby dissolve the ___________ in the enamel even at the _________________________

• ____________________, _________ and _________ may also act as secondary chelators

• ________ and coworkers observed that there is a simultaneous _______________________ of organic component by ___________ and the _____________ of __________________ by the process of ___________

phosphatase

chondroitin sulfatase

hyaluronidase

proteases

ENZYMATIC THEORY

• _____________ (dissolves apatite)

• _________________ (dissolves dentinal chondroitin sulfate)

• _________________
(dissolves dentinal hyaluronic acid)

• ____________ (dissolve dentinal collagen)

apatite

dentinal chondroitin sulfate

dentinal hyaluronic acid

dentinal collagen

ENZYMATIC THEORY

• phosphatase (dissolves __________)

• chondroitin sulfatase (dissolves _________________________)

• hyaluronidase
(dissolves __________________________)

• proteases (dissolve _________________)