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Type 1 Diabetes
Autoimmune beta cell destruction and ABSOLUTE INSULIN DEFICIENCY
Type 2 Diabetes
Progressive loss of insulin secretion plus long standing INSULIN RESISTANCE
Gestational diabetes
Placental hormones block insulin effect, 20-24 weeks into pregnancy. VERY PRONE TO HAVE DIABETES AFTER GIVE BIRTH
Path of insulin
Stim by INC in blood glucose levels
Pancreas releases insulin
Insulin stims glycogen formation in liver and uptake by cells
Path of glucagon
Stim by DEC in blood glucose levels
Pancreas releases glucagon
Glucagon stims glycogen breakdown in the liver
Risk factors for T2DM (8)
Have prediabetes
Have high blood pressure
Overweight
45 years or older
Have parent, siblings with type 2 diabetes
Active less than 3x a week
Had gestational diabetes
Given birth to 9lb baby
What is the PRE diabetes stats
Fasting Plasma Glucose (100 - 125 mgdL)
HbA1C (5.7 - 6.4%)
2h Plasma Glucose (140 - 199 mgdL during oral glucose tolerance test)
ADA diagnostic criteria for Diabetes Mellitus
FPG = > 126 mgdL
2h PG = > 200 gdL during OGTT
lowF1C = > 6.5%
Random PG = > 200 mgdL PLUS symptoms of hyperglycemia
Fasting means how long of no calorie intake?
8 hours
Lifestyle modifications used for T2DM
Plate method
Sleep
Alcohol
Social
Plate method
Half of plate - fruit/veggies
Quarter - protein
Quarter - grains
Sulfonylureas suffix
Gl -
-ide
Physiologic changes of a sulfonylurea
Stim beta cells to release more insulin
Sulfonylureas exercise effects
INC risk of hypoglycemia
INC sensitivity to sunlight
Metformin physiologic change
DEC hepatic production of glucose
INC muscle tissue sensitivity to insulin
1st line of defense
Metformin exercise effects and what impact it has on measurements
INC HR
INC RPE
Hypoglycemia
HR AND RPE WONT BE ACCURATE
USE METS, TALK TEST, or OMNI SCALE
DPP-4 Inhibitors suffix
-gliptin
DPP-4 Inhibitors physiologic changes
Block action of DPP-4
MORE GLP-1 and GIP
DPP-4 Inhibitors exercise effect
NONE!
GLP-1 and Dual GLP-1/GIP RECEPTOR AGONISTS suffix
-glutide
Receptor agonists physiologic changes
activate the receptors for GLP-1 and GIP on tissues
Receptor agonists exercise effects
Tachycardia, hypotension
Hypoglycemia symptoms
shaking tremors
lips/tongue tingly
headache/confusion
dizziness/weakness
HYPERglycemia symptoms
excessive thirst
inc hunger
inc urination
fruity breath
Contraindication to exercise
BG LESS THAN 70
BG EQUAL OR ABOVE 250 in combo with KETONES IN URINE
BG EQUAL OR ABOVE 350
Hypoglycemia exercise and feeding BG values
Less than 70 NO EXERCISE
Less than 80 EAT 30 GRAMS OF CHO WAIT 15 MINS
80 - 100 EAT 15 - 30 G OF CHO
Hyperglycemia BG exercise values
ABOVE OR EQUAL 250 WITH KETONES NO EXERCISE
ABOVE OR EQUAL 350 NO EXERCISE
Diabetes aerobic exercise FITT for T2DM
F: 3-7 d/wk NO MORE THAN 2 DAYS CONSECUTIVE SKIPPED
I: mod to vig talk test, METS
T: 150 min/wk
Diabetes resistance prescription T2DM
F: NO MORE THAN 2 NON-CONSECUTIVE DAYS
I: as tolerated
T: sets and reps
T: multiplanar multijoint exercise, each major tendon muscle unit
Diabetes flexibility prescription T2DM
F: 2-3 d/wk
I: tight, slight discomfort NO PAIN
T: 10-30 s, 2-4 reps
T: static, dynamic
Diabetes balance prescription
F: 2-3 d/wk
I: RPE 10-14
T: any duration
T: lower body and core
How to progress Resistance training
Inc LOAD first
Inc reps
Inc sets
Inc frequency last
Benefits of resistance training
Improved lean muscle mass trickle down effect
INC fat oxidation
Greater capillary density
Optimal pre exercise BG
90-250
Best training?
COMBO
During combo training do which type first?
Resistance then aerobic!
Why should we stay hydrated during exercise?
Inc risk of overheating
How long after eating should they exercise?
WITHIN 2 HOURS
What should get eaten after exercise?
Complex carb snack
Retinopathy is what?
Carbs build up in iris and cause blindness
Avoid these with retinopathy in exercise
Vigorous aerobic or resistance
Jumping/jarring
Head down
Valsalva maneuver
Peripheral neuropathy what is it?
High BG levels damage sensory neurons and blood vessels
Peripheral neuropathy exercise precautions
FALL RISK
Nonweight bearing activities
Mental health
General feeling of well being, manage stress, contribute to community, work productively
Mental illness
Health condition that impacts thinking, behavior, mood, relatability, ADLs
Mental health indicators
Optimism
Clear thinking
Stable relationships
Flexibility
Productive behavior
Mental illness indicators
Withdrawal, numb, helpless, mood swings, harming yourself, cant do ADLS
Depress DSM5 Definition
Mood disorder involving a persistent low mood or loss of interest in actvities
Depression cognitive effects
negative self talk, pessimistic,hopelessness and helplessness
Depression somatice effects
Extreme fatigue, altered sleep, fluctuation in weight
Types of depression
Major depressive disorder
Perinatal
Premenstrual dysphoric disorder
Persistent depressive disorder
Seasonal affective disorder
Atypical
MDD
depressed mood, no pleasure
Perinatal
before or after childbirth
premenstrual dysphoric childbirth
mood swings, irritable, depressed mood or anxiety before menstruation
Persistent depressive disorder
MORE THAN 2 YEARS
Seasonal affective disorder
seasonal
Atypical
Has MDD with mood reactivity, INCREASED appetite, sleep, heavy limbs, and rejection sensitive
Anxiety DSM5 definition
excessive worry and apprehension that occurs more days than not for at least 6 months
Anxiety cognitive effects
cant concentrate, on edge, going down rabbit hole, irritable, restlessness
Anxiety somatic effects
trembling muslce tension, tachycardia, tachypnea, GI upset, dry mouth and easily fatigue
Generalized anxiety disorder
excessive worry about events
OCD
unwanted reoccuring repetitive behaviors
PTSD
distress due to being exposed to traumatic event
Panic disorder
intense recurrent panic attacks
social anxiety disorder
extreme anxiety in social situations
General causes of these illlness’
Autonomic dysfunction
Imbalance in brain systems
Impaired neurotransmitter release (GABA, serotonin, epi/norepi)
Inflammatory dysregulation
Regions of brain linked to anxiety and depression
Prefrontal cortex - Logical response and reasoning shut down by anxiety
Anterior cingulate cortex - AMPLIFY fear signals from amygdala
Amygdala - Response to fear, INC in size in anxiety
Depression anxiety stress scales 10
overall level of distress that is sensitive to and can be used to track effectiveness of treatment
Hospital anxiety and depression scale
identify hospital pts who need more psych evaluation and assistance
GAD 7 for anxiety and PQH 9
screening tools used to assess severity of symptoms
What mode is recommended in depressed pts
Submaximal exercise test
Recommended CRF tests
6 min walk WITH SUPPORT
Frenz ergocycle test
What needs to be discussed before testing a person with anxiety
INC HR and Respiratory rate with sweating may seem like an anxiety symptom
Antidepressents classes and their effect
SSRI - dizzy
SNRI - dizzy
Misc - dizzy and rapid heart beat
DIZZY =
FALL RISK
3 classes of antianxiety meds
Benzodiazepines - dizzy, memory loss, confusion, amnesia, breathing bad
Azapirone - dizzy drowsy, tachycardia, GI UPSET, headaches, nervousness, numb, tingling insomnia
Beta Blockers - -olol bradycardia, hypotension, fatigue, dizziness, sleepy
How exercise helps depression
Monoamine boost - INC serotonin, dopamine, norepi
BDNF brain plasticity - form new hippocampal neurons and synapses
Lower inflammation - releases antiinflammatory myokines
Kynurenine sink - protects blood brain barrier and prevents brain toxicity
How exercise helps anxiety
Stress axis tuning - cortisol responses become smaller and smaller
Endocannaboids/endorphins - calms and reduces tension after working out
anxiety senstivity retraining - exercise is a like a panic attack, trains body to react appropriately
sleep and rumination break - interupts worry loop
Aerobic FITT for anxiety/depression
F: 5 days mod 3 days vig
I: Mod 40-59% HRR RPE 12-13 Vig 60-89% HRR RPE 14-17
T: Mod 75 m/wk Vig 75 m/wk
T: Rhythmic, large muscle groups, walk bike swim
Resistance FITT for anxiety/depression
F: 2/3 d/wk 48 hours apart
I: 60-70 1RM 7 - 6 RIR 40-50% 1RM 5-4 RIR for 65 over and deconditioned
T: 8-12 reps, 2-4 sets, 2-3 min rest
T: multijoint/multiplanar for all muscle tendons
Behavioral strategies for anxiety and depression
Focus on rapport, empathy
NONADHERENCE SHOULD BE EXPECTED
Start with open ended goal
Enhance self efficacy
Remind of benefits
Positive rewards
Buddy or support system