Exam 4 Antibodies

IgA

Heavy chain name: alpha

Secreted form: dimer

found in mucosa

Fc receptor: Fc alpha R

Cell Bearing Fc receptor: Granulocytes, Monocytes

Ab Effect: Activation

Prevalence: 10-15%

amount of binding options: 4

Half Life: 3 days

Functions:

Neutralization: ++

Opsonizing: +

FCR Signaling w/ NK cells: -

FCR Signaling w/ Mast Cells: -

Activating complement: +

IgD

Heavy chain name: Delta

Secreted form: monomer

Fc receptor: Fc Delta R

Cell Bearing Fc receptor: Basophils, Mast Cells

Ab Effect: Make AMPs (anti-microbial peptides)

Prevalence: roughly 1%

amount of binding options: 2

Half Life: 2 days

Functions:

Neutralization: -

Opsonizing: -

FCR Signaling w/ NK cells: -

FCR Signaling w/ Mast Cells: -

Activating complement: -

IgE

Heavy chain name: Epsilon

Secreted form: monomer

allergy attack

Fc receptor: Fc Epsilon R

Cell Bearing Fc receptor: Granulocytes

Ab Effect: Degranulation

Prevalence: >1%

amount of binding options: 2

Half Life: 2 days

Functions:

Neutralization: -

Opsonizing: -

FCR Signaling w/ NK cells: -

FCR Signaling w/ Mast Cells: +++

Activating complement: -

IgG

Heavy chain name: Gamma

Secreted form: monomer

Fc receptor: Fc Gamma R

Cell Bearing Fc receptor: Phagocytes

Ab Effect: Phagocytosis

Second Cell bearing receptor: Granulocytes, NK cells

Second AB Effect: Killing

Prevalence: 75%

amount of binding options: 2

Half Life: 3-4 weeks

Functions:

Neutralization: ++

Opsonizing: +

FCR Signaling w/ NK cells: +

FCR Signaling w/ Mast Cells: +

Activating complement: +

IgM

Heavy chain name: mu

Secreted form: pentamer

Fc receptor: Fc Mu R

Cell Bearing Fc receptor: B-cells

Ab Effect: B cell development

Prevalence: 10%

amount of binding options: 10

Half Life: 4 days

Functions:

Neutralization: +

Opsonizing: +

FCR Signaling w/ NK cells: -

FCR Signaling w/ Mast Cells: -

Activating complement: +++