Mineralocorticoid Pharmacology Terms & Definitions Study Set

What is fludrocortisone?

synthetic version of aldosterone prescribed for salt retention; longer half life than aldosterone

What two factors mediate aldosterone release?

ACTH and RAAS system

What are some symptoms of excessive aldosterone levels (hyperaldosteronism)?

hypokalemia, slight increase in plasma Na, metabolic alkalosis, increased plasma volume, HTN

What are some symptoms of mineralocorticoid deficiency?

Na wasting, decreases in extracellular fluid volume, hyponatremia, hyperkalemia, acidosis. hypotension

What is deoxycorticosterone (DOC)?

a precursor of aldosterone that is primarily under control of ACTH

True or False: Fludricortisone has both glucocorticoid and mineralocorticoid activity.

true

True or False: At lower doses, fludrocortisone is more specific towards glucocorticoid receptors.

false; to mineralocorticoid receptors

What is the difference in action between glucocorticoids and mineralocorticoids?

gluc- influence inflammation; mineral- salt retention

What is spironolactone used to treat?

primary aldosteronism, reversal of manifestations of aldosteronism, hirsutism in women, diuretic, HF

What is eplerenone used for?

HTN

True or False: Spironolactone is more specific than eplerenone.

false; spironolactone also binds androgen receptors