Pharmacology Lecture 26: Narcan Training

What receptor do opioids act on?

Mu receptor

What effects do opioids produce?

Morphine-like

What are opioids primarily used for?

Pain relief

When does an opioid overdose occur?

Too many opioids bind to receptors

What response to opioids leads to overdose death?

Respiratory failure

What are the five main symptoms of an opioid overdose?

1. Shallow breathing

2. Breathing noises

3. Cyanosis

4. Slow pulse

5. Unresponsive

What is the purpose of Naloxone?

Reverse opioid overdose

What does Naloxone restore to reverse opioid overdose?

Breathing

When does Naloxone wear off?

30 mins - 2 hours

Is the action of Naloxone shorter or longer than opioids?

Shorter

What is the main delivery method for Nalaxone?

Intranasal

What is the mechanism of Naloxone?

Competes and displaces opioids at receptors

What is the pregnancy consideration for Naloxone?

Crosses placenta

What are the steps for responding to an opioid overdose?

1. Attempt to wake

2. Call 911

3. Naloxone administration

4. Place patient in recovery position if responsive

5. Provide post administration care

6. If stops responding, begin CPR and repeat Naloxone

What is the first step to waking an opioid overdose person?

Make noise

If the opioid overdose person is not responsive to noise, what should you do to wake them?

Sternum rub (Pain)

What are the two main reasons why emergency services is needed for an opioid overdose?

1. Naloxone is temporary

2. Overdose may be non-opioid

What are the two Rescue Breathing steps for opioid overdoses?

1. Tilt head back

2. Give two breaths

3. Give one breath every 6 seconds

What is prevented by the recovery position?

Choking from vomiting