amphetamine

synthetic - non catecolamine

mechanism

indirect

prominent CNS action

pharmacodynamics

absorption and fate as: ephedrine

excretion: acidic urine

CNS actions

stimulation of cortex - reticular activating system -midbrain - spinal cord

manifested by

euphoria - wakefulness - mental activity

analeptic action

enhances analgesia of morphine

facilates mono and polysynaptic transmission

decreases appetite

sympathomimetic tolerance

anorexigenic and psychic action

sympathomimetic addiction

prolonged use

sympathomimetics uses

narcolepsy

ADHD

obesity

psychic depression - mydriatic

nocturnal enuresis - nasal decongestant

symoathomimetics adverse effects

palpitation - losing of weight

hypertension - insomnia

arrhythmia - hallucination

mydriasis - convuisions and coma

anxiety - psychosis

anorexia

contraindications

adrenaline

insomnia

prostatic hypertrophy

MAO inhibitors

vasopressor sympathomimetics

hypotension

noradrenaline : IV

ephedrine : IV

phenylephrine

midodrine : oral

derivative

methamphetamine

more CNS action

less peripheral action

anorexigenic

mazindol : CNS stimulant for short term

phentermine :

appetite suppressant

used with diet and exercise to treat obesity

risks → high BP - high cholesterol - diabetes

stimulant

amfepramone : antideoressant