skin infections, pseudomonas

herpesvirus characteristics

dsDNA, large, enveloped

herpesvirus therapy

inhibits viral DNA polymerase

HPV characteristics

dsDNA, circular genome

HPV-associated cancers

cervical, anal, vaginal, vulvar, penile, oropharyngeal

oncogenes expressed in high risk HPVs

E6 and E7

small pox virus characteristics

dsDNA, poxviridae, large, enveloped

smallpox virus symptoms

macular rash → blisters → scars

what distinguished smallpox from VZV

simultaneous outbreak of the vesicular rash

measles virus symptoms

cough, coryza, conjunctivits, maculopapular rash

measles dx

koplik spots

measles and mumps virus characteristics

paramyxovirus, -sense RNA, enveloped

mumps symptoms

swollen glands, fever, headache

rubella virus characteristics

togaviridae.; ss + sense RNA, enveloped

rubella symptoms

fever, malaise, rash, URT infection, 3 days of rash

pseudomonas characteristics

gram negative, facultative anaerobe, rob shaped, motile

CFTR mutations

affects the flow of Cl- ions through membranes

how does p. aeruginosa kill cells

exotoxin A blocks protein synthesis, elastase, phospholipase, type III and VI secretion systems

type 3 secretion system

needle-like secretion system injecting effectors straight into host cell

p. aeruginosa effector functions

actin cytoskeleton disruption, blocks phagocytosis, induce cell death, cytotoxicity

P. aeruginosa during chronic infections

increased exopolysaccharide expression, loss of immunogenicity, loss of virulence, host-adapted mechanism, increased antibiotic resistance

alginate overproduction results in

mucoid pseudomonas with increase antibiotic resistance and protection against host immune responses

AlgU

controls expression of alginate expression

s. epi coagulase

negative

staph aureus virulence factors

catalase-positive, coagulase-positive, protein A binds to Fc, pigment

mycobacterium leprae

acid-fast bacterium