NSAIDs / Non-opioid analgesics

Non-opioid antipyretic

Acetaminophen

MOA for non-opioid antipyretic

• blocks pain impulses peripherally by inhibiting prostaglandin synthesis.

Why might an non-opioidantipyretic be used for NSAID

does not cause the NSAIDs/aspirin-related Gi tract irritation or bleeding

Indications for non-opioid antipyretic

Pain, fever, alt. for aspirin

Contraindications for non-opioid analgesic

• medication allergy

• liver dysfunction

• possible liver failure

• G6PD deficiency 

Interactions for non-opioid analegsic

Alcohol, hepatotoxic drugs

Antidote for acetaminophen toxicity

acetylcysteine regimen 

What is something NSAID do that acetaminophen can’t

reduce inflammation

Max amount for acetaminophen

4g

Special consideration for acetaminophen

OTC drugs contain acetaminophen, ensure to keep track of these to not exceed 4g per day

NSAID

ibuprofen, naproxen, ketorolac, indomethacin

Indications for NSAID

Pain, fever, inflammation

MOA for non-selective NSAID

inhibit prostaglandin synthesis

Side effects for non-selective NSAID

GI upset, GI bleeding, renal toxicity, rash, headache

Do not give if patient has what?

peptic ulcer disease

Non-opioid analgesic Cox 2 Inhibitor

Celecoxib

Indications for Cox 2

osteoarthritis, rheumatoid arthritis

MOA for Cox 2

inhibiting Cox-2 enzyme which decreases prostaglandin synthesis = decrease in pain and inflammation

Side effects for Cox-2

risk for thrombosis, MI, stroke, GI bleeding, rash

Contraindications for Cox-2

allergy to aspirin, NSAIDS, or sulfenamides

Non-opioid analgesic Salicylate

Aspirin

MOA for Salicylate

inhibit prostaglandin synthesis, decreases platelet aggregation

Uses for Salicylate

prevent MI, fever, inflammation, mild/mod pain

Side effects for Salicylate

tinnitus, GI upset, GI bleeding, rash

Do not give to who (Salicylate )

Kids

Ket side effects of salicylate

A-abdominal pain, salicylism, P-peptic ulcer disease, I- intestinal bleeding, R-Reyes syndrome (kids) I-itchy rash, N-noise