DOACs and dietary precautions

examples of direct oral anticoagulants (DOACs)?

dabigatran (Pradaxa)

rivaroxaban (Xarelto)

apixaban (Eliquis)

what does dabigatran (Pardaxa) do?

thrombin inhibitor

antidote for dabigatran (Pradaxa)

Praxbind

where is dabigatran (Pradaxa) metabolized and excreted?

metabolized in liver

renally excreted

dabigatran (Pradaxa) onset, half-life, and monitoring

onset: 1-6 hrs

half-life: 12-17 hrs

no routine lab monitoring

what does rivaroxaban (Xarelto) do?

inhibits factor Xa

antidote for rivaroxaban (Xarelto)

4F-PCC (Kcentral)

where is rivaroxaban (Xarelto) metabolized and excreted?

metabolized in the liver

renally excreted

rivaroxaban (Xarelto) onset, half-life, monitoring

onset: 2-4 hrs

half-life: 6-12 hrs

no routine lab monitoring

what does apixaban (Eliquis) do?

inhibit factor Xa

what is the antidote for apixaban (Eliquis)?

4F-PCC (Kcentral)

where is apixaban (Eliquis) metabolized and excreted?

metabolized in the liver

GI excretion

apixaban (Eliquis) onset, half-life, monitoring

onset: 3-4 hrs

half-life: 9-14 hrs

no routine lab monitoring

if a patient is taking any of these drugs, what are they at risk for?

bleeding

dietary precautions when taking anticoagulants

keep vitamin K intake consistent → avoid sudden large changes in vitamin K-rich foods

• dark leafy greens

• broccoli, brussels sprouts, cabbage

• green tea

• liver

many products have potential interactions