Non-NMDA glutamate receptors

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Last updated 9:49 AM on 10/6/26
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12 Terms

1
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What changes in receptor composition can effect activity?

- Agonist and coagonist potency.

- Deactivation rate

- Ion permeation.

- Channel conductance

- GluN2 subunits affect pharmacology NMDAR

2
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What are the types of non-NMDA glutamate receptors?

- AMPA Receptor

- Kainate Receptor

3
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What genes code for AMPA receptors?

- GluA1

- GluA2

- GluA3

- GluA4

4
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What genes code for Kainate receptors?

- GluK1

- GluK2

- GluK3

- GluK4

- GluK5

5
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What are the differences between NMDA and Non-NMDA receptors?

- NMDA receptors are highly permeable to Ca²⁺, whereas non-NMDA receptors (e.g., AMPARs) generally are not.

- This permeability is determined by the amino acid sequence in the M2 domain.

- NMDA receptors have a positively charged arginine residue in the M2 domain, whereas non-NMDA receptors typically have an uncharged amino acid, such as glutamine.

<p>- NMDA receptors are highly permeable to Ca²⁺, whereas non-NMDA receptors (e.g., AMPARs) generally are not.</p><p>- This permeability is determined by the amino acid sequence in the M2 domain.</p><p>- NMDA receptors have a positively charged arginine residue in the M2 domain, whereas non-NMDA receptors typically have an uncharged amino acid, such as glutamine.</p>
6
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Describe the function of AMPA receptors.

- AMPA receptors mediate fast excitatory transmission.

- AMPA receptors are co-expressed with NMDA receptors.

7
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What drugs act on AMPA receptors?

- CNQX and NBQX can block AMPA receptors and Kainate receptors which allows identification of AMPA receptors from NMDA receptors.

- Perampanel is an AMPA receptors antagonist via binding to an allosteric site.

- Ampakines act at AMPA receptors which enhance response to glutamate.

8
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Describe metabotropic glutamate receptors.

- GPCRs (class C family).

- Contain a large extracellular N-terminal domain where glutamate binds too.

- 8 subtypes: mGluR1 to mGluR8.

- 8 subtypes rae split into 3 groups.

<p>- GPCRs (class C family).</p><p>- Contain a large extracellular N-terminal domain where glutamate binds too.</p><p>- 8 subtypes: mGluR1 to mGluR8.</p><p>- 8 subtypes rae split into 3 groups.</p>
9
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Describe group 1 metabotropic glutamate receptors.

- Only mGluR1 and mGluR3.

- Post-synaptic (excitatory)

- GaQ/11 linked which increases Ca2+

10
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Describe group 2 metabotropic glutamate receptors.

Only includes mGluR2 and mGluR3.

11
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Describe group 3 metabotropic glutamate receptors.

- Includes mGluR4, mGluR6, mGluR7, and mGluR8

- Pre-synaptic neurone (inhibitiory).

- Gai linked to decrease cAMP production.

12
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How do drugs act on metabotropic glutamate receptors?

- Drugs can distinguish between subtypes.

- Antagonists for group 1 can treat epilepsy, pain and parkinson's.

- Antagonists for group 2 can act as cognition enhancers.

- Positive allosteric modulators for group 3 can treat Parkinson's and anxiety.