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osteoblasts
builds bones
osteoclasts
breakdown bones
how much is body have calcium
99%
parathyroid hormone
released when blood calcium is low
how is PTH stimulated
calcium itself signals parathyroid gland to increase PTH secretion
4 main effects of PTH
increase osteoclast activity, increase intestinal absorption of calcium thru vit D, increase calcium absorption in kidneys, decrease reabsorption of PO43- so calcium can be free
vitamin d
increases blood calcium - stimulates intestinal absorption of calcium
vitamin d deficiency
decreases calcium absorption from intestines which decreases overall blood calcium; stimulates PTH which breaks down bone
vitamin d is what of both
vitamin and hormone
calcitonin
peptide hormone that decreases blood calcium in response to high blood calcium; secreted by parafollicular cells in thyroid glands; may also stimulate osteoblast activity
what two things increase blood calcium
PTH and vitamin D
osteoporosis
too much bone breakdown and not enough bone formation
increases fragility and susceptible to fractures