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hepatic portal vein
• The drug is swallowed and undergoes absorption from the GIT through the mesenteric circulation to the
Jejunal region
is the primary absorption site
gastric emptying
Altered ________ affects arrival of the drug in the duodenum
Peristaltic movement
affects the contact time with the epithelial cells
GI enzymes or decomposed by the acid pH
The drug may be digested by ______________ of the stomach
mucosal epithelial cells
• The drug may irritate ____________ or complex with the contents of the GI tract.