Unit 3

Quantitative Train

phenotype values in the population take on some continuous distribution

Quantitative Trait Locus (QTL)

a genetic variant that is associated with a quantitative trait

Expression Quantitative Trait Locus (eQTL)

a genetic variant that is associated with gene expression

Cis-eQTL

an associated genetic variant near the gene whose expression it is associated with

Trans-eQTL

an associated genetic variant distant from the gene whose expression it is associated with

Methylation Quantitative Trait Locus (meQTL or mQTL)

a genetic variant that is associated with methylation level at CpG site or locus in general

Variance Quantitative Trait Locus (vQTL)

a genetic variant that is associated with variance in a quantitative trait

Threshold Model

relates quantitative traits to binary traits

Residual Heritability

a sub-type of heritability when model includes additional terms

Correlation

a measure of the linear relationship between two variables

Genome-Based Restricted Maximum Likelihood (GREML)

estimates relatedness and does something a lot like using a sample of relatives