Acute Phase Reactants

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7 Terms

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C-Reactive Protein (CRP)

Roles: Opsonization, Agglutination, & Complement activation

Incr rapidly in inflammation

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Serum Amyloid A (SAA)

Role: Chem messenger and activator of monocytes and macrophages

Incr rapidly in infection or injury

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Complement

Roles: Promote inflammation, Opsonization, & Direct lysis of cells

Nine proteins normally inert activated by microorganisms or antibodies/other immune stimulants

Cascade rxn

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Alpha1-Antitrypsin (AAT)

Role: Protect normal cell from damage by immune substances

Neutralizes proteases

REgulates proinflammatory cytokin production

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Haptoglobin

Role: Anti-oxidant

Binds free Hgb for removal by liver

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Fibrinogen

Role: Coagulation

Seals breaks in skin to prevent further invasion or spread of outside pathogens

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Ceruloplasmin

Role: Regulation of Fe2+ metabolism & Antioxidant