Mismatch Repair

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9 Terms

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Role of MR

To repair a mismatch in the newly made DNA strand whereby DNA polymerase put the wrong nucleotide

Maintaining micro satellite stability

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Disorders associated

Lynch Syndrome/ hereditary nonpolyposis colorectal cancer syndrome

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<p>Working mechanism</p>

Working mechanism

Similar to NER

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When does it occur

After DNA replication

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What are the mutated genes

MLH1 and MSH2

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What are microsatellite

These are DNA fragments that are repeative

<p>These are DNA fragments that are repeative</p>
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Instability in the microsatelities results into

Colon cancer

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what are microstatelities

dna fragments that hv a repeatitant sequences

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