QAS Sodium Bicarbonate 8.4% DTP

Comprehensive vocabulary flashcards covering the drug class, pharmacology, metabolism, indications, contraindications, precautions, side effects, presentation, and pharmacokinetics of sodium bicarbonate 8.4%.

Drug Class

Alkalising agent.

Pharmacology.

A hypertonic solution that acts as a buffer; excess hydrogen ions react with bicarbonate to form carbon dioxide and water, assisting in restoring plasma pH to within normal ranges.

Metabolism

Metabolised to CO2 and H2O

Contraindications

Nil

Precautions

Nil

Side Effects

1. Cerebral oedema.

2. Congestive heart failure.

Presentation

Vial, 100 mL sodium bicarbonate 8.4%.

Pharmacokinetics

Onset: Immediate

Duration: Variable

Half-life: Variable

Indications

1. Cardiac arrest: secondary to suspected hyperkalaemia (e.g. chronic renal failure) or propranolol overdose,

2. Cardiac arrest secondary to tricyclic antidepressant (TCA) toxicity.

3. Significant injury with potential for crush syndrome

4. TCA poisoning (with QRS >0.14 AND terminal R wave in aVR)

5. Sodium channel blockade due to non-TCA poisoning (with QRS >0.14 AND terminal R wave in aVR)

6. Suspected hyperkalemia (with QRS widening ABD/OR AV dissociation)

Adult Doses for:

1. Cardiac Arrest (suspected hyperkalemia and propranolol OD)

2. Significant injury with potential for crush syndrome

3. Suspected hyperkalemia

4. Sodium channel blockade (due to non-TCA poisoning)

IV & IO: 100ml single dose only

Adult doses for:

1. Cardiac arrest ( TCA overdose)

2. TCA poisoning

IV & IO: 100ml repeated every 5 mins, total max dose 300ml.