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gap junctions
direct cytoplasmic transfer between adjacent cells
contact-dependent signals
surface to surface contact between membranes
hormones
released from tissue and travels to target cell through blood
neurotransmitters
released through neurons to adjacent effector
neurohormone
released from neuron and travels to target cell through blood
paracrine agent
released into interstitial fluid and affects neighboring target cell
autocrine agent
released into interstitial fluid and affects the cell that released it
receptors
a protein associated with the membrane or cellular interior which will bind a chemical messenger and exert an effect
lipophilic messengers
diffuse directly through the membrane to an internal receptor
lipophobic messengers
must enter cell through transport or bind to a surface receptor
agonist
chemical messenger that binds to a receptor and triggers a cell’s response
antagonist
molecule that competes with another for a receptor and binds to the receptor but doesn’t trigger a cellular response