AKI Type Identification Points

Drugs associated with macrocircular prerenal AKI?

• Diuretics

• SGLT2is

Drugs associated with microcircular prerenal AKI?

• NSAIDs

• Calcineurin inhibitors (tacrolimus, cyclosporine)

• ACEIs, ARBs, ARNis

Hypotension and dehydration are associated with which type of AKI?

Prerenal

Ascites are associated with which type of AKI?

Prerenal

Prerenal AKI urine Na

<20 mEq/L

Prerenal AKI FENa

<1%

Prerenal AKI urine sediment

Hyaline casts or normal

Drugs associated with intrinsic AKI acute tubular necrosis

• Amphotericin B

• Aminoglycosides

• Cisplatin

• Contrast dye

Drugs associated with intrinsic AKI acute interstitial nephritis

• NSAIDs — ~6 months after initiation

• Beta-lactams, ciprofloxacin, PPIs — 14 days after initiation

Nonspecific symptoms are associated with which type of AKI?

Intrinsic, acute tubular necrosis

Fever is associated with which type of AKI?

Intrinsic, acute interstitial nephritis

Maculopapular rash is associated with which type of AKI?

Intrinsic, acute interstitial nephritis

Intrinsic AKI urine Na

>40 mEq/L

Intrinsic AKI FENa

>2%

Intrinsic AKI urine sediment

Granular casts, cellular debris

Drugs associated with postrenal AKI

• Acyclovir — especially drug-induced crystal nephropathy or calculi

• Antineoplastics

Distended bladder is associated with which type of AKI?

Postrenal

Enlarged prostate is associated with which type of AKI?

Postrenal

Postrenal AKI urine Na

>40 mEq/L

Postrenal AKI FENa

Variable

Postrenal AKI urine sediment

Cellular debris