Cross-talk DCs and CD169+ macrophages

What are the 3 immune status of tumour. Give the defenition and mechanism of tumour invasion

Sketch the cancer-immunity cycle

RAP TIIK

Explain hot/cold/excluded tumours. What type of t cell response they have and what therapy can be given to them

What are the component of a cancer vaccine

Sketch the pathway for how tumour vaccines work

vaccine antigen enters tissue
↓
immature DC takes up antigen
↓
adjuvant activates/matures DC
↓
DC migrates to draining lymph node
↓
DC presents antigen to naive T cells

What do CD169⁺ macrophages do?

CD169⁺ macrophage captures antigen
↓
transfers antigen to DC
↓
DC cross-presents antigen
↓
CD8 T-cell activation

It also has low proteolytic activity so it doesnt degrade the antigen and waits to transfer it to dc

CD169⁺ macrophages collaborate with cDC1 to prime CD8⁺ T cells. True or false

True

Antibody-, nanobody-, and liposome-mediated targeting of antigen to CD169⁺ APCs produces strong T-cell priming in mouse and human model systems. True or false (go through the research-they-did notes)

True