PBSI 235: Exam 2 Quiz Questions

Eitan

dopaminergic pathway: mesocortical system

cognition

dopaminergic pathway: mesolimbic system

reward and pleasure

dopaminergic pathway: nigrostriatal system

movement

dopaminergic pathway: tuberoinfundibular pathway

secretion of prolactin

the monamines are:

dopamine, serotonin, norepinephrine, epinephrine

the cathecholamines are:

dopamine, norepinephrine, epinephrine

Which enzyme is involved with the biosynthesis of cathecholamines (check all that apply):

Tyrosine hydroxylase

DOPA decarboxylase

Dopamine beta-hydroxylase

5-HTP decarboxylase

Which enzyme is involved with the inactivation of cathecholamines (check all that apply):

Monoamine oxidase (MAO) A

Monoamine oxidase (MAO) B

Catechol-O-methyltransferase (COMT)

Which enzyme is involved with the biosynthesis of serotonin (check all that apply):

Tryptophan hydroxylase

DOPA decarboxylase

5-HTP decarboxylase

Which enzyme is involved with the inactivation of serotonin (check all that apply):

Monoamine oxidase (MAO) A

The excitatory receptors for dopamine are (check all that apply):

D1

The inhibitory receptors for dopamine are (check all that apply):

D2

The receptors for norepinephrine are (check all that apply):

Alpha 1

Beta 1

The receptors for serotonin are (check all that apply):

5HT1A

5HT2A

5HT3

5HT4

The autoreceptors for serotonin are (check all that apply):

5HT1A

The ionotropic receptors for serotonin are (check all that apply):

5HT3

Which enzyme is involved with the biosynthesis of acetylcholine (check all that apply):

Choline acetyltransferase

Which enzyme is involved with the inactivation of acetylcholine (check all that apply):

Acetylcholinesterase (AChE)

The ionophoric receptor(s) for acetylcholine are (check all that apply):

Nicotinic receptor

The metabotropic receptor(s) for acetylcholine are (check all that apply):

Muscarinic receptor

Please indicate which of the following statements is/are correct regarding acetylcholine (check all that applies):

• Curare is a drug that blocks nicotinic acetylcholine receptors

• The primary means by which the postsynaptic action of acetylcholine is terminated is via enzymatic degradation

The autoimmune disorder, myasthenia gravis, attacks ACH receptors causing muscles to weaken and become less response but drugs help alleviate symptoms by

Inhibiting the activity of acetylcholinesterase

Which pair of transmitters are the primary excitatory and inhibitory (respectively) transmitters in the brain?

d) glutamate; GABA

Please indicate which of the following is/are true regarding retrograde neurotransmitters:

• They produced by the postsynaptic neurons and stimulating the presynaptic neurons

• Endocannabinoid and nitric oxide are examples for molecules that can serve as retrograde neurotransmitters

What feature of neuropeptide is not classified as classical neurotransmitters?

a) They do not synthetized in the terminal, rather in the soma.

The retrograde neurotransmitters are (check all that apply):

• Nitric oxide

• Endocannabinoid

The ionotropic receptors for glutamate are (check all that apply):

NMDA receptor

AMPA receptor

kainate receptor

Which of the following metabotropic receptors for glutamate coupled to Gq (check all that apply):

mGluR 1

mGluR 5

The  ionotropic receptors for GABA are (check all that apply):

GABA-A

GABA-C

Which of the following receptors for GABA coupled to Gi (check all that apply):  

GABA-B

Microdialysis is a procedure for:

d) Measuring neurotransmitters secretion

Microdialysis features:

• Poor temporal resolution

• Poor spatial resolution

Biosensors features:

• Fast temporal resolution

• Excellent spatial resolution

Stereotaxic surgery is used for (check all that applies):

a) Producing Brain Lesions

b) Implanting electrodes

e) Implanting cannulas

Sham surgery is (check all that applies):

a) Duplicates most of the step of producing a brain lesion

b) A placebo procedure

Which of the following procedures is used to record the brain’s metabolic activity (check all that applies):

a) 2-deoxyglucose (2-DG)

d) Functional MRI (fMRI)

Immunohistochemistry is a procedure for:

c) Labeling neurons

Optogenetics is a procedure for:

b) Stimulating electrical activity

Optogenetics features:

• Light-responsive channels

• Control neuronal signaling

• Quick turn neurons on or off

DREADD features:

• Engineered muscarinic receptors

• Less-invasive

• Control neuronal signaling

• Prolong turn neurons on or off

Which type of staining will be most appropriate to study the amygdala’s efferent connections:

a) Anterograde labeling method