GPCR Signal Transduction Pathway - Phosphatidylinositol System

0.0(0)
Studied by 0 people
call kaiCall Kai
learnLearn
examPractice Test
spaced repetitionSpaced Repetition
heart puzzleMatch
flashcardsFlashcards
GameKnowt Play
Card Sorting

1/7

encourage image

There's no tags or description

Looks like no tags are added yet.

Last updated 8:02 PM on 11/13/24
Name
Mastery
Learn
Test
Matching
Spaced
Call with Kai

No analytics yet

Send a link to your students to track their progress

8 Terms

1
New cards

What enzyme is activated by the GPCR?

Phospholipase C (PLC)

<p>Phospholipase C (PLC)</p>
2
New cards

Substrate of phospholipase C?

PIP2

<p>PIP2</p>
3
New cards

Products of PIP2 cleavage?

IP3 and DAG

<p>IP3 and DAG</p>
4
New cards

Role of IP3?

Releases Ca²⁺ from the ER

<p>Releases Ca²⁺ from the ER</p>
5
New cards

Function of DAG?

Activates PKC (with Ca²⁺)

<p>Activates PKC (with Ca²⁺)</p>
6
New cards

Effect of active PKC?

Phosphorylates proteins

7
New cards

Role of Ca²⁺ as a messenger?

Activates enzymes like calmodulin

8
New cards

List of Secondary Messengers:

  • cAMP: Activates PKA for phosphorylation of proteins, affecting metabolism and gene expression

  • IP3: Releases Ca²⁺ from the ER, triggering calcium-dependent processes

  • DAG: Activates PKC with Ca²⁺, leading to protein phosphorylation

  • Ca²⁺: Activates enzymes like calmodulin, affecting muscle contraction and signaling

  • PIP3: Activates growth and survival pathways, like AKT