Unit 3 Neuro Test

curare

nicotinic receptor agonist

familial parkinsons

Mutations in Parkin and a-Synuclein; 10 % cases

sarin gas

inhibits cholinesterase; ACh buildup

myasthenia gravis

autoimmune; destroys ACh receptors

@ 0 mv

Influx Na = efflux of K

ACh group

Amines

Precursor for catecholamines

tyrosine

How does ACh slow heart rate?

increase GIRK channels; decrease T-type Ca channels

MPTP injections in mice

destroys neurons in substatia nigra, cell death in dopaminergic neurons; develop Parkinsons

glycine group

amino acids

why don’t naked mole rats feel spice

can’t synthesize substance P

Tryptophan precursor

5HT(serotonin)

Glutamate precursor

GABA

Tyrosine precursor

DA (dopamine)

reuptakes GABA

GAT

role of signal sequence on neuropeptides

targets prepropeptides to the lumen of the rough ER

C elegans needs _ to shit

IP3

paracrine

endocrine

through blood

2nd messenger intra and extracellular sources

Ca

histamine precursor

histidine

ACh precursor

choline

Reserpine

lowers blood pressure; sympathetic nervous system activity

good for: high blood pressure; schizophrenzia

bad: depression; low blood pressure

Tricyclics

revent reuptake of catecholamines/serotonin after release

Monoamine oxidase inhibitors (MAOIs)

Block the enzyme monoamine oxidase (MAO) from catabolizing

catecholamines and serotonin into inactive forms